{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:32:09Z","timestamp":1787027529712,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T00:00:00Z","timestamp":1772928000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T00:00:00Z","timestamp":1772928000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To describe the first Italian experience with teplizumab administered under a compassionate use programme for adults with Stage 2 type 1 diabetes (T1D), and to evaluate its feasibility, safety and early metabolic outcomes in a real\u2010life clinical setting outside formal clinical trials.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Three adult women (aged 20\u201340\u2009years) with Stage 2 T1D, identified through islet autoantibody screening and dysglycaemia assessment, received a 14\u2010day intravenous course of teplizumab (Tzield) in a day\u2010hospital setting. Infusions were managed by a multidisciplinary team with standardised pre\u2010medication and monitoring. Clinical and laboratory parameters (vital signs, lymphocyte count, liver enzymes, HbA1c, C\u2010peptide, continuous glucose monitoring metrics) were recorded at baseline and after 3\u2009months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Treatment was overall well tolerated. One patient developed mild transient elevation of transaminases and lymphopenia, resolving spontaneously. A second patient experienced a 40% reduction in lymphocyte count without symptoms. The third developed a mild cytokine\u2010release syndrome on Day 5, which resolved with supportive therapy but led to treatment discontinuation due to anxiety. At 3\u2010month follow\u2010up, all patients maintained stable glycaemic control and preserved \u03b2\u2010cell function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Teplizumab administration under compassionate use proved feasible and safe in a real\u2010life academic context, consistent with pivotal trial data. The experience underscores the importance of a structured multidisciplinary approach, integrating endocrinologists, anaesthesiologists, nurses and psychologists to optimise adherence, safety and patient engagement during early disease\u2010modifying immunotherapy in presymptomatic T1D.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.70626","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T04:20:31Z","timestamp":1773030031000},"page":"4326-4334","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Teplizumab in Stage 2 Type 1 Diabetes: Clinical Practice Experience on Feasibility in 3 Adult Patients"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8088-4947","authenticated-orcid":false,"given":"V.","family":"Guarnotta","sequence":"first","affiliation":[{"name":"Unit of Endocrinology, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties Policlinico Paolo Giaccone, Universit\u00e0 degli Studi di Palermo  Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Pant\u00f2","sequence":"additional","affiliation":[{"name":"Unit of Endocrinology, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties Policlinico Paolo Giaccone, Universit\u00e0 degli Studi di Palermo  Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Vigneri","sequence":"additional","affiliation":[{"name":"Unit of Endocrinology, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties Policlinico Paolo Giaccone, Universit\u00e0 degli Studi di Palermo  Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Piombo","sequence":"additional","affiliation":[{"name":"Unit of Endocrinology, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties Policlinico Paolo Giaccone, Universit\u00e0 degli Studi di Palermo  Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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