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Accordingly, single\u2010dose intranasal oxytocin reduces food intake and improves glucose tolerance. We investigated the effects of a continuous intravenous oxytocin infusion on\n                      <jats:italic>ad libitum<\/jats:italic>\n                      food intake, appetite sensations, and postprandial metabolism.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In a randomised, placebo\u2010controlled, double\u2010blind, crossover study, overnight fasted participants with obesity underwent two 4.5\u2010hour intravenous infusions of oxytocin (0.2 international units\/min) and placebo (saline), respectively, on separate days interposed by a wash\u2010out period of a minimum of seven days. After 60\u2009min of infusion, participants ingested a standardised liquid mixed meal containing 1.5\u2009g paracetamol (for evaluation of gastric emptying). Appetite sensations were assessed by visual analogue scales, and concentrations of plasma glucose as well as glucose and appetite\u2010regulating hormones were measured. After four hours, food intake (primary endpoint) was assessed by an\n                      <jats:italic>ad libitum<\/jats:italic>\n                      meal test.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty\u2010four individuals (12 women, median age 41.5 (interquartile range (IQR) 28.5;55.3) years, body mass index 36.2 (32.1;37.6) kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      , mean glycated haemoglobin 34\u2009\u00b1\u2009standard deviation (SD) 3.5\u2009mmol\/mol) completed the study.\n                      <jats:italic>Ad libitum<\/jats:italic>\n                      food intake was similar between oxytocin and saline infusions (mean 714\u2009\u00b1\u2009SD 382 vs. 707\u2009\u00b1\u2009385\u2009kcal). Compared with placebo, oxytocin did not affect sensations of appetite nor circulating glucose, insulin, C\u2010peptide, glucagon, glucagon\u2010like peptide 1, glucose\u2010dependent insulinotropic polypeptide, cholecystokinin, or paracetamol.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      In individuals with obesity, 4.5\u2010hour intravenous infusion of oxytocin causing supraphysiological plasma concentrations of ~400\u2009pg\/mL has no effect on\n                      <jats:italic>ad libitum<\/jats:italic>\n                      food intake, appetite sensations, plasma glucose levels, circulating concentrations of glucose and appetite\u2010regulating hormones, or gastric emptying.\n                    <\/jats:p>\n                  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