{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T14:53:27Z","timestamp":1792508007857,"version":"4.5.0"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Mazdutide, a dual GLP\u20101 and glucagon receptor agonist, shows promise for weight loss and glycaemic control. This study evaluates its efficacy in non\u2010diabetic patients with obesity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>\n                      A search of Cochrane Library, PubMed, Google Scholar and\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">clinicaltrials.gov<\/jats:ext-link>\n                      identified randomised controlled trials (RCTs) of mazdutide in adults (\u2265\u200918\u2009years) with obesity. Meta\u2010analysis was performed using RevMan 5.4 with random\u2010effect models.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Five RCTs were included. Mazdutide significantly reduced percentage body weight (MD\u2009=\u2009\u221212.42%, 95% CI: \u221216.15% to \u22128.68%), absolute body weight (MD\u2009=\u2009\u22129.76\u2009kg, 95% CI: \u221213.15 to \u22126.37\u2009kg) and waist circumference (MD\u2009=\u2009\u22127.98\u2009cm, 95% CI: \u221210.24 to \u22125.72\u2009cm). Systolic blood pressure (MD\u2009=\u2009\u22127.68\u2009mmHg), total cholesterol (MD\u2009=\u2009\u22120.57\u2009mmol\/L) and LDL (MD\u2009=\u2009\u22120.37\u2009mmol\/L) also decreased. Adverse events were slightly increased (RR\u2009=\u20091.12). Dose\u2010wise meta\u2010regression showed significant effects (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u2009\u22120.99, 95% CI: \u22121.81 to \u22120.16;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0187).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Mazdutide effectively reduces weight, waist circumference and blood pressure but may cause mild to moderate adverse events. Findings are limited by the small number of RCTs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.70643","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T10:09:34Z","timestamp":1773137374000},"page":"4464-4473","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Efficacy and Safety of Mazdutide in Managing Overweight and Obesity Among Non\u2010Diabetic Adults: A Meta\u2010Analysis of Randomised Controlled Trials"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-9895-7170","authenticated-orcid":false,"given":"Muhammad Hassan","family":"Azam","sequence":"first","affiliation":[{"name":"Department of Medicine Dow University of Health Sciences  Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Hussain","family":"Azam","sequence":"additional","affiliation":[{"name":"Department of Medicine Dow University of Health Sciences  Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khair\u2010un\u2010Nisa","family":"Azam","sequence":"additional","affiliation":[{"name":"University of Karachi  Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Ahmed","family":"Azam","sequence":"additional","affiliation":[{"name":"Shaheed Benazir Bhutto Dewan University  Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Khalid","family":"Afridi","sequence":"additional","affiliation":[{"name":"Department of Medicine Dow University of Health Sciences  Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9051-6081","authenticated-orcid":false,"given":"Saad Ahmed","family":"Waqas","sequence":"additional","affiliation":[{"name":"Department of Medicine Dow University of Health Sciences  Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Sharjeel","family":"Abbas","sequence":"additional","affiliation":[{"name":"Gomal Medical College Khyber Medical University  Peshawar Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasibullah","family":"Aminpoor","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Kabul University of Medical Sciences \u201cAbu Ali Ibn Sina\u201d  Kabul Afghanistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raheel","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Laboratory Newcastle upon Tyne Hospitals, Medicine Freeman Hospital  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,10]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(25)00397-6"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2411528"},{"key":"e_1_2_13_4_1","volume-title":"Obesity and Overweight","author":"World Health Organization (WHO)","year":"2025"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.70040"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2021.12.012"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/iid3.391"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2018.3788"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(24)01498\u20103"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1603827"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2021.101088"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2022.101691"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2025.105791"},{"key":"e_1_2_13_14_1","volume-title":"PROSPERO","author":"Azam M. 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