{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T03:01:44Z","timestamp":1792292504000,"version":"4.4.0"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The comparative effectiveness of bariatric surgery (BS) and glucagon\u2010like peptide\u20101 receptor agonists (GLP\u20101 RAs) for weight loss among patients with obesity remains uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      MEDLINE, EMBASE and CENTRAL were searched to 5 October 2025. Pooled mean differences (MDs) for change in weight, body mass index (BMI), glycaemic indices, lipid profile and blood pressure were calculated using random\u2010effects models with heterogeneity quantified by\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      . Outcomes were assessed separately according to time duration. Meta\u2010regression was performed for the primary outcome of change in BMI.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fifteen studies (20\u2009594 participants) were included. Weight loss did not differ significantly at 6\u2009months (MD \u201312.19\u2009kg;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.13), but favoured BS at \u2264\u20091\u2009year (MD \u221216.97\u2009kg;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02) and &gt;\u20091\u2009year (MD \u221219.78\u2009kg;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). BMI reduction consistently favoured BS at 6\u2009months (MD \u22126.77\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02), \u2264\u20091\u2009year (MD \u22125.10\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and &gt;\u20091\u2009year (MD \u22126.61\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). HbA1c reduction was greater with BS beyond one year (MD \u22121.69%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and fasting glucose was lower overall with BS (MD \u22121.22\u2009mmol\/L;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03). Serum lipids and blood pressure showed no significant between\u2010group differences. Meta\u2010regression demonstrated larger BMI reductions with BS in older patients, male patients and those with higher baseline BMI.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Although substantial heterogeneity was present, BS was associated with greater and sustained reductions observed over multi\u2010year follow up in weight, BMI and glycaemic indices compared to GLP\u20101 RAs, with similar effects on serum lipids and blood pressure, supporting its use in appropriately selected adults with obesity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.70676","type":"journal-article","created":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T05:03:27Z","timestamp":1774328607000},"page":"4901-4914","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Weight Loss Outcomes Between\n                    <scp>GLP<\/scp>\n                    \u20101 Receptor Agonists and Bariatric Surgery in Adults With Obesity: A Systematic Review, Meta\u2010Analysis and Meta\u2010Regression"],"prefix":"10.1111","volume":"28","author":[{"given":"Muhammad","family":"Tahir","sequence":"first","affiliation":[{"name":"Department of Medicine Dow University of Health Sciences  Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marium Ali","family":"Meghani","sequence":"additional","affiliation":[{"name":"Department of Medicine Dow University of Health Sciences  Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Salik","family":"Uddin","sequence":"additional","affiliation":[{"name":"Department of Medicine Dow University of Health Sciences  Karachi 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