{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T11:00:18Z","timestamp":1785236418613,"version":"3.55.0"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:00:00Z","timestamp":1774483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:00:00Z","timestamp":1774483200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Whether associations between the body roundness index (BRI) and mortality differ across population settings in metabolic dysfunction\u2010associated steatotic liver disease (MASLD) remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We analysed two nationally representative cohorts: NHANES (1999\u20132018;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20097723; US population) and CHARLS (2011\u20132020;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20096553; Chinese population). Cox proportional hazards regression with restricted cubic splines was used to assess dose\u2013response relationships. Between\u2010cohort heterogeneity was evaluated using\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      statistics.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In NHANES (mean BMI, 31.99\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ; 924 deaths over median follow\u2010up of 8.9\u2009years), BRI demonstrated a significant linear association with all\u2010cause mortality (hazard ratio [HR], 1.18 per SD; 95% confidence interval [CI], 1.049\u20131.327;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006). In CHARLS (mean BMI, 25.73\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ; 110 deaths over median follow\u2010up of 7.3\u2009years), no significant association was observed (HR, 0.91; 95% CI, 0.749\u20131.101;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.327). Between\u2010cohort heterogeneity was substantial (\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200980.7%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.023). In NHANES, the triglyceride\u2010glucose (TyG) index was associated with 33.8% (95% CI, 18.2%\u201352.4%) statistical attenuation of the BRI\u2010mortality association. The null finding in CHARLS likely reflects insufficient power (14% to detect HR\u2009=\u20091.18) rather than evidence against an association, highlighting the need for adequately powered studies.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>BRI demonstrates a significant linear association with mortality in the US MASLD population. In the Chinese elderly MASLD population, statistical power was insufficient to draw definitive conclusions about BRI\u2010mortality associations. The observed between\u2010cohort heterogeneity likely reflects multiple factors, including differences in age structure, obesity phenotype, mortality ascertainment methods, and potentially genuine population\u2010specific characteristics. These findings underscore the importance of population\u2010specific validation before extrapolating Western\u2010derived BRI thresholds to Asian populations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.70685","type":"journal-article","created":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T10:44:47Z","timestamp":1774521887000},"page":"4961-4974","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Body Roundness Index and All\u2010Cause Mortality in Metabolic Dysfunction\u2010Associated Steatotic Liver Disease: A Dual\u2010Cohort Study"],"prefix":"10.1111","volume":"28","author":[{"given":"Zijian","family":"Li","sequence":"first","affiliation":[{"name":"Department of General Surgery, Beijing Hospital, National Center of Gerontology Institute of Geriatric Medicine, Chinese Academy of Medical Sciences  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7963-6146","authenticated-orcid":false,"given":"Shishu","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Beijing Hospital, National Center of Gerontology Institute of Geriatric Medicine, Chinese Academy of Medical Sciences  Beijing People's Republic of China"},{"name":"Chinese Academy of Medical Sciences Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Beijing Hospital, National Center of Gerontology Institute of Geriatric Medicine, Chinese Academy of Medical Sciences  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinxin","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Beijing Hospital, National Center of Gerontology Institute of Geriatric Medicine, Chinese Academy of Medical Sciences  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuhai","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Beijing Hospital, National Center of Gerontology Institute of Geriatric Medicine, Chinese Academy of Medical Sciences  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianming","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Beijing Hospital, National Center of Gerontology Institute of Geriatric Medicine, Chinese Academy of Medical Sciences  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"An","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Beijing Hospital, National Center of Gerontology Institute of 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