{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T04:03:25Z","timestamp":1780459405357,"version":"3.54.1"},"reference-count":48,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:00:00Z","timestamp":1774483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:00:00Z","timestamp":1774483200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004191","name":"Novo Nordisk","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004191","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Although semaglutide 2.4\u2009mg has demonstrated significant weight loss efficacy in clinical trials, real\u2010world data, particularly with regard to clinically complex and underrepresented populations, remain limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The study aims to assess the real\u2010world effectiveness and patient\u2010reported outcomes associated with the use of semaglutide 2.4\u2009mg in individuals with severe and complex obesity. The study also intends to characterize weight loss response in pre\u2010defined subgroups of patients and to identify predictors of weight loss using machine learning.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      SEMASEARCH is a retrospective multicentric observational cohort embedded within the French early\u2010access program for semaglutide 2.4\u2009mg. A total of 1100 patients with severe obesity (BMI \u2265\u200940\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      with at least one treated obesity\u2010related complication) were retrospectively included from 11 expert obesity centers, based on prospectively collected data at baseline, 6\u2009months, and 12\u2009months. Subgroups include patients with a history of bariatric surgery, binge eating disorder, hypothalamic obesity, age\u2009\u2265\u200960\u2009years or altered body composition, BMI \u2265\u200960\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      , and those receiving psychotropic medications. Assessments include clinical, biological, and body composition data, as well as standardized questionnaires evaluating eating behaviour, physical activity, sleep, quality of life, digestive symptoms, and mental health.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Primary Outcome<\/jats:title>\n                    <jats:p>Body weight change since treatment initiation, with assessment at 6 and 12\u2009months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Secondary Outcomes<\/jats:title>\n                    <jats:p>Clinically meaningful weight loss (\u2265\u200910%) at 12\u2009months, metabolic improvements, patient\u2010reported outcomes, body composition changes, and tolerance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Expected Impact<\/jats:title>\n                    <jats:p>SEMASEARCH will provide real\u2010world evidence on Semaglutide 2.4\u2009mg use in patients living with severe and complex obesity. It will also address major knowledge gaps in specific populations underrepresented in clinical trials and generate predictive models of weight loss response.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.70697","type":"journal-article","created":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T09:16:14Z","timestamp":1774516574000},"page":"4602-4609","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["SEMASEARCH Study Design: Real\u2010World Evaluation of Semaglutide 2.4\u2009mg in Adults With Severe Obesity Underrepresented in Clinical Trials"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8085-2881","authenticated-orcid":false,"given":"Pierre","family":"Bel Lassen","sequence":"first","affiliation":[{"name":"Assistance Publique\u2010H\u00f4pitaux de Paris (AP\u2010HP), Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital, Service de Nutrition Sorbonne Universit\u00e9  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