{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:11:30Z","timestamp":1790957490850,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100031478","name":"NextGenerationEU","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100031478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Studies evaluating automated insulin delivery (AID) in type 2 diabetes are limited in number and often conducted in small cohorts. We aimed to summarize efficacy and safety data through a systematic review and meta\u2010analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>We searched MEDLINE, PubMed, Web of Science, and CENTRAL databases and performed hand searching until July 1, 2025. We included randomized controlled trials enrolling individuals with type 2 diabetes, evaluating AID against other glucose\u2010lowering treatments, and reporting 24\u2010h time spent in the 70\u2013180\u2009mg\/dL glucose range (TIR 70\u2013180\u2009mg\/dL) as an outcome. Risk of bias was assessed through the RoB2 tool.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of nine studies, accounting for 714 adults with type 2 diabetes, were included. AID was associated with improved TIR 70\u2013180\u2009mg\/dL (mean difference [MD] 18.43%, 95% confidence interval [CI]: 12.40 to 24.46; low certainty), time above range (TAR; low certainty), TAR &gt;\u2009250\u2009mg\/dL, mean glucose, standard deviation (moderate certainty), and HbA1c (moderate certainty) compared to controls, without differences in time below range (TBR; moderate certainty), TBR &lt;\u200954\u2009mg\/dL, and coefficient of variation. Despite similar total daily insulin doses, AID led to a modest gain in body weight (MD 1.58\u2009kg; 95% CI: 0.75 to 2.40) compared to controls. Severe adverse events, including severe hypoglycemia, were rare. No episodes of diabetic ketoacidosis were reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In individuals with type 2 diabetes, AID is associated with short\u2010term improvements in glycemic control, although the certainty of evidence is low to moderate.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trail Registration:<\/jats:bold>\n                      PROSPERO 2025\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/www.crd.york.ac.uk\/PROSPERO\/view\/CRD420251083874\">CRD420251083874<\/jats:ext-link>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.70708","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T07:31:27Z","timestamp":1774596687000},"page":"5091-5100","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Efficacy and Safety of Automated Insulin Delivery in People With Type 2 Diabetes: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3454-7330","authenticated-orcid":false,"given":"Sergio","family":"Di Molfetta","sequence":"first","affiliation":[{"name":"Endocrinology Unit University Hospital \u201cConsorziale Policlinico\u201d of Bari  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8165-7531","authenticated-orcid":false,"given":"Ludovico","family":"Di Gioia","sequence":"additional","affiliation":[{"name":"Endocrinology Unit Ecclesiastical Entity Regional General Hospital \u201cF. 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