{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T13:31:48Z","timestamp":1783431108193,"version":"3.54.6"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the glycaemic outcomes of a novel calibration\u2010free hybrid closed\u2010loop (HCL) system in adolescents and adults with type 1 diabetes (T1D).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This multicentre pivotal trial enrolled 123 participants (21 adolescents aged 14\u201317\u2009years and 102 adults aged \u2265\u200918\u2009years) with T1D. All participants used the MicroTech Medical Equil S HCL system, which integrates a patch insulin pump with the AIDEX G7 calibration\u2010free continuous glucose monitor. After a 2\u2010week run\u2010in period with the pump in manual mode, automated insulin delivery (auto mode) was enabled for a 12\u2010week study phase. The primary outcome was the change in CGM\u2010derived time in range (TIR; 70\u2013180\u2009mg\/dL) from the run\u2010in to the study phase.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The median time spent in automated mode was 88.4% (IQR 76.6%\u201392.0%) in adolescents (mean age 15.5\u2009\u00b1\u20091.0\u2009years) and 91.6% (IQR 87.8%\u201394.1%) in adults (mean age 39.4\u2009\u00b1\u200913.2\u2009years). TIR increased significantly from 63.7% to 68.3% in adolescents (mean difference 4.6% [95% CI: 0.7\u20138.6];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.024) and from 69.6% to 78.0% in adults (mean difference 8.0% [95% CI: 6.3\u20139.8];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Time below range (&lt;\u200970\u2009mg\/dL) decreased from 4.1% to 3.0% in adolescents (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.032) and from 3.8% to 2.7% in adults (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). HbA1c decreased from 7.0% to 6.9% in adolescents (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.011) and from 6.6% to 6.3% in adults (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). No episodes of severe hypoglycaemia or diabetic ketoacidosis occurred. Patient\u2010reported outcomes showed significantly higher treatment satisfaction and convenience scores at study end compared with baseline.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this first pivotal trial of a novel integrated HCL system, 3\u2010month use was safe and significantly improved glycaemic control\u2014increasing TIR while reducing HbA1c and hypoglycaemia\u2014accompanied by enhanced treatment satisfaction in both adolescents and adults with T1D.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>Chinese Clinical Trial Register Identifier: ChiCTR2300074200<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.70709","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T06:12:24Z","timestamp":1774937544000},"page":"5101-5112","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Glycaemic Outcomes of a Novel Model\u2010Predictive\u2010Control\u2010Based Hybrid Closed\u2010Loop System in Chinese Adolescents and Adults With Type 1 Diabetes: A Multicentre Pivotal Trial"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4537-8969","authenticated-orcid":false,"given":"Yang","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Endocrinology The Eighth Medical Center of PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medical Identification Air Force Medical Center  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health National Children's Regional Medical Center Hangzhou  Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yimei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The Eighth Medical Center of PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianshu","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Union Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology  Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8665-7983","authenticated-orcid":false,"given":"Xia","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Metabolism and Endocrinology The Second Xiangya Hospital of Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The Second Affiliated Hospital, Zhejiang University School of Medicine  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufeng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Beijing Pinggu Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5984-3342","authenticated-orcid":false,"given":"Xiaohong","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Zhejiang Provincial People's Hospital  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Genetics &amp; Metabolism and Endocrinology Wuhan Children's Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology  Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linqi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Metabolism, and Genetic Children's Hospital of Soochow University  Suzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Zhu","sequence":"additional","affiliation":[{"name":"Microtech Medical Device (Hangzhou) Co. 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