{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T20:49:52Z","timestamp":1789505392336,"version":"build-2803163510"},"reference-count":59,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hypertriglyceridemia is an independent risk factor for atherosclerotic cardiovascular disease (ASCVD). We aimed to evaluate the efficacy and safety of apolipoprotein C\u2010III (ApoC\u2010III) inhibitors in patients with hypertriglyceridemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Electronic databases were systematically searched for randomised controlled trials (RCTs) comparing ApoC\u2010III inhibitors (Volanesorsen, Olezarsen and Plozasiran) with placebo. A frequentist network meta\u2010analysis was performed. Continuous outcomes were presented as mean differences (MDs), and dichotomous outcomes as risk ratios (RRs), both with 95% confidence intervals (CIs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 15 RCTs involving 3934 patients were included. All ApoC\u2010III inhibitors demonstrated significant reductions in TG, except for Volanesorsen 100\u2009mg Q1W and Olezarsen 10\u2009mg Q4W. Olezarsen 80\u2009mg administered every 4\u2009weeks had the highest SUCRA ranking for TG reduction (MD: \u221263.26; 95% CI: \u221270.04 to \u221256.47;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). Moreover, ApoC\u2010III inhibitors were associated with a significant reduction in the incidence of pancreatitis (HR: 0.16, 95% CI: 0.07\u20130.33,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). None of the agents significantly increased the risk of serious adverse events.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>ApoC\u2010III inhibitors significantly improved triglyceride levels and other lipid parameters and, most importantly, substantially reduced the risk of acute pancreatitis. Future trials are needed to evaluate their effects on cardiovascular outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.70717","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T04:33:17Z","timestamp":1775017997000},"page":"5149-5162","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy and Safety of Apolipoprotein C\u2010\n                    <scp>III<\/scp>\n                    Inhibitors in Hypertriglyceridemia: A Network Meta\u2010Analysis of Randomised Controlled Trials"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-3083-857X","authenticated-orcid":false,"given":"Mohammed A.","family":"Elbahloul","sequence":"first","affiliation":[{"name":"Faculty of Medicine Kafr El\u2010Shaikh University  Kafr El Shaikh 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