{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:58:00Z","timestamp":1786121880298,"version":"build-2736575974"},"reference-count":57,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T00:00:00Z","timestamp":1776038400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T00:00:00Z","timestamp":1776038400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Diabetic retinopathy (DR) is linked to elevated risks of cerebrovascular diseases. Whether sodium\u2010glucose cotransporter\u20102 inhibitors (SGLT2i) reduce stroke risk in patients with type 2 diabetes (T2D) and DR remains uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective cohort study using the TriNetX Research Network. Adults with T2D and DR initiating SGLT2i versus dipeptidyl peptidase\u20104 inhibitors\/metformin were identified. After 1:1 propensity score matching, ischemic stroke (IS) and hemorrhagic stroke (HS) risks at 1, 3 and 5\u2009years were assessed using Cox models, with hazard ratios (HRs) and number needed to treat (NNT) estimated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>After matching, 13\u2009778 per group were included. SGLT2i use was associated with reduced HS risk at 1\u2009year (HR: 0.76; 95% CI, 0.56\u20130.93), 3\u2009years (HR: 0.79; 95% CI, 0.59\u20130.90), and 5\u2009years (HR: 0.73; 95% CI, 0.60\u20130.89; NNT 100). IS risk reduction emerged at 5\u2009years (HR: 0.92; 95% CI, 0.85\u20130.99; NNT 34). For patients with early\u2010stage DR and HbA1c &gt;\u20097%, HS risk decreased at 1\u2009year (HR: 0.57; 95% CI, 0.37\u20130.89), 3\u2009years (HR: 0.61; 95% CI, 0.41\u20130.83), and 5\u2009years (HR: 0.64; 95% CI, 0.44\u20130.84). Sensitivity analyses showed consistent 5\u2010year reductions in HS risk among patients with neuropathy, nephropathy and chronic kidney disease, with NNTs of 91, 59 and 84, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>SGLT2i was associated with lower stroke risk, particularly HS, in patients with T2D and DR. These findings suggest a potential cerebrovascular benefit, although prospective studies are needed to confirm this association.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.70744","type":"journal-article","created":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T09:38:12Z","timestamp":1776073092000},"page":"5614-5626","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of\n                    <scp>SGLT2<\/scp>\n                    Inhibitor With Stroke in Type 2 Diabetes With Diabetic Retinopathy: A Multicenter Electronic Health Record Data Study"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-5557-4558","authenticated-orcid":false,"given":"Kuo\u2010En","family":"Chen","sequence":"first","affiliation":[{"name":"School of Medicine, College of Medicine, Taipei Medical University  Taipei 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