{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:58:01Z","timestamp":1786121881044,"version":"build-2736575974"},"reference-count":50,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T00:00:00Z","timestamp":1776038400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T00:00:00Z","timestamp":1776038400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["183596"],"award-info":[{"award-number":["183596"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008582","name":"McGill University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008582","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To examine whether on\u2010treatment changes in kidney function and cardiometabolic markers are associated with the magnitude of heart failure (HF) risk reduction across large\u2010scale trials of glucagon\u2010like peptide\u20101 receptor agonists (GLP\u20101RAs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>We searched PubMed and Embase from inception to 29 January 2026 for randomised, placebo\u2010controlled GLP\u20101RA trials enrolling \u2265\u20091000 adults with type 2 diabetes and\/or overweight or obesity and a follow\u2010up of at least one year. The primary outcome was clinical HF events (hospitalisation for HF, with or without urgent HF visits). We pooled hazard ratios (HRs) using random\u2010effects meta\u2010analysis and performed mixed\u2010effects meta\u2010regression to test whether between\u2010group changes in annualised estimated glomerular filtration rate (eGFR) improvement, body weight, systolic blood pressure (SBP), and heart rate were associated with the treatment effect on clinical HF events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eleven trials were included (90\u2009867 participants; 2863 clinical HF events). GLP\u20101RAs reduced the risk of clinical HF events (HR 0.86, 95% CI 0.80 to 0.93,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001,\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>2<\/jats:italic>\n                      <\/jats:sup>\n                      \u2009=\u20092.1%). In meta\u2010regression, annualised eGFR improvement was significantly associated with greater HF risk reduction (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.009); at the trial level, each 1\u2009mL\/min\/1.73\u2009m\n                      <jats:sup>2<\/jats:sup>\n                      \/year greater improvement in eGFR corresponded to a 21% lower hazard of clinical HF events (95% CI 7% to 32%). In contrast, changes in body weight, SBP, and heart rate were not associated with HF risk reduction.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Across large\u2010scale GLP\u20101RA trials, greater annualised eGFR improvement was associated with larger reductions in clinical HF events. Annualised eGFR change may serve as a useful marker of HF benefit with GLP\u20101RAs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.70749","type":"journal-article","created":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T09:27:08Z","timestamp":1776072428000},"page":"5649-5657","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Estimated Glomerular Filtration Rate Change and Heart Failure Events With\n                    <scp>GLP<\/scp>\n                    \u20101 Receptor Agonists: A Meta\u2010Analysis and Meta\u2010Regression of Randomised\u00a0Controlled Trials"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7031-2446","authenticated-orcid":false,"given":"Masashi","family":"Hasebe","sequence":"first","affiliation":[{"name":"Canada Excellence Research Chair Program in Genomic Medicine McGill University  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Department of Human Genetics McGill University  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Department of Diabetes, Endocrinology and Nutrition Kyoto University Graduate School of Medicine  Kyoto Japan"},{"name":"Department of Diabetes and Endocrinology Medical Research Institute KITANO HOSPITAL, PIIF Tazuke\u2010Kofukai  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3971-1327","authenticated-orcid":false,"given":"Hisashi","family":"Kamido","sequence":"additional","affiliation":[{"name":"Nephrology Center Toranomon Hospital Kajigaya  Kawasaki Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6071-4660","authenticated-orcid":false,"given":"Chen\u2010Yang","family":"Su","sequence":"additional","affiliation":[{"name":"Canada Excellence Research Chair Program in Genomic Medicine McGill University  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Quantitative Life Sciences Program McGill University  Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6271-9609","authenticated-orcid":false,"given":"Yamato","family":"Keidai","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Endocrinology and Nutrition Kyoto University Graduate School of Medicine  Kyoto Japan"},{"name":"Department of Diabetes and Endocrinology Medical Research Institute KITANO HOSPITAL, PIIF Tazuke\u2010Kofukai  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5334-7687","authenticated-orcid":false,"given":"Daisuke","family":"Yabe","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Endocrinology and Nutrition Kyoto University Graduate School of Medicine  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8863-2413","authenticated-orcid":false,"given":"Satoshi","family":"Yoshiji","sequence":"additional","affiliation":[{"name":"Canada Excellence Research Chair Program in Genomic Medicine McGill University  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Department of Human Genetics McGill University  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Quantitative Life Sciences Program McGill University  Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(17)32520\u20105"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.125.325602"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(25)02105\u20101"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.70048"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2025.01.022"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfaf193"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.70121"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.15122"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc26\u2010S011"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.123.032463"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2019010007"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.23876\/j.krcp.20.104"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.0000000839"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jrsm.12"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2015.09.002"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1186"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7109.629"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1097\u20100258(19991030)18:20<2693::aid\u2010sim235>3.0.co;2\u2010v"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1509225"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1603827"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1607141"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1612917"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(18)32261\u2010X"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(19)31149\u20103"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1901118"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2108269"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2307563"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2403347"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2501006"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213\u20108587(18)30268\u20107"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.121.055459"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2022.12.028"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.14175"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc23\u20100231"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010024\u201003015\u20105"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc25\u20101080"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2021.5151"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaf457"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213\u20108587(21)00242\u20104"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2020.10.042"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213\u20108587(20)30313\u20102"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c2289"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010023\u201002418\u20100"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2313917"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2306963"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010023\u201002526\u2010x"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.657"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213\u20108587(18)30104\u20109"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dom-pubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dom.70749","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/dom.70749","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dom.70749","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T07:33:09Z","timestamp":1786087989000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.onlinelibrary.wiley.com\/doi\/10.1111\/dom.70749"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,13]]},"references-count":50,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1111\/dom.70749"],"URL":"https:\/\/doi.org\/10.1111\/dom.70749","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/DOM.70749\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.70749\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.70749\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.70749\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.70749\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.70749\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.70749\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.70749\/v2\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.70749\/v1\/review3","asserted-by":"object"}]},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"value":"1462-8902","type":"print"},{"value":"1463-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,13]]},"assertion":[{"value":"2026-02-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}