{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:33:19Z","timestamp":1791909199821,"version":"4.3.4"},"reference-count":69,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T00:00:00Z","timestamp":1776038400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T00:00:00Z","timestamp":1776038400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100011725","name":"Servier","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>We evaluated the impact of scenario\u2010based multifactorial control on the 3\u2010year incidence of fatal\/non\u2010fatal cardiovascular disease (CVD) and associated healthcare costs in Asian patients with type 2 diabetes (T2D).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      We applied the validated \u2018ABC\u2019 model to simulate the 3\u2010year impact of attaining multiple treatment targets (HbA\n                      <jats:sub>1c<\/jats:sub>\n                      \u2009&lt;\u20097%, blood pressure [BP]\u2009&lt;\u2009130\/80\u2009mmHg, risk\u2010stratified LDL\u2010C target [ABC], smoking cessation and weight reduction) on the incidence of fatal\/non\u2010fatal CVD (ischaemic heart disease and stroke) in patients with T2D enrolled from 11 Asian countries\/jurisdictions in the Joint Asia Diabetes Evaluation (JADE) Register. We estimated the costs of these simulated CVD events and potential cost savings with multifactorial intervention.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Amongst 103\u2009958 patients with T2D (53.4% men, 12.0% current smokers, mean [SD] age 57.6 [11.8], HbA\n                      <jats:sub>1c<\/jats:sub>\n                      7.96 [1.87], systolic BP 132.0 [17.4] mmHg, LDL\u2010C 2.6 [0.95] mmol\/L, BMI 26.2 [4.5] kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ), 17\u2009151 (16.5%) had prior CVD and 86\u2009807 (83.5%) had no CVD at baseline. In the CVD group, 1.5% achieved all three ABC targets and 5.1% in the nonCVD group at baseline. In the CVD group, the estimated incidence rate for CVD was 61.60 per 1000\u2010person\u2010years (PY), and 11.65 per 1000\u2010PY in the non\u2010CVD group. Simulated achievement of all three ABC targets reduced the incidence rates by 35.1%\u201340.01% per 1000\u2010PY in the CVD group and by 30.2%\u20138.13% per 1000\u2010PY in the non\u2010CVD group. In China, these scenario\u2010based simulations might avert 1\u2009177\u2009682 CVD events per year with a potential saving of US$ 11 292 823 476.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Multifactorial management of cardiometabolic risk factors may have a substantial impact on CVD prevention, with cost savings in patients with T2D.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.70755","type":"journal-article","created":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T09:31:40Z","timestamp":1776072700000},"page":"5670-5683","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of Simulated Risk Factor Management on Cardiovascular Disease and Costs in Type 2 Diabetes Using the\n                    <scp>ABC<\/scp>\n                    Model"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6214-6924","authenticated-orcid":false,"given":"Lee\u2010Ling","family":"Lim","sequence":"first","affiliation":[{"name":"Department of Medicine, Faculty of Medicine University Malaya  Kuala Lumpur Malaysia"},{"name":"Department of Medicine and Therapeutics The Chinese University of Hong Kong, Prince of Wales Hospital  Shatin Hong Kong SAR"},{"name":"Asia Diabetes Foundation  Hong Kong SAR"},{"name":"Baker Heart and Diabetes Institute  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric S. H.","family":"Lau","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics The Chinese University of Hong Kong, Prince of Wales Hospital  Shatin Hong Kong SAR"},{"name":"Asia Diabetes Foundation  Hong Kong SAR"},{"name":"Hong Kong Institute of Diabetes and Obesity The Chinese University of Hong Kong, Prince of Wales Hospital  Shatin Hong Kong SAR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4034-1286","authenticated-orcid":false,"given":"Juliana N. M.","family":"Lui","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics The Chinese University of Hong Kong, Prince of Wales Hospital  Shatin Hong Kong SAR"},{"name":"Asia Diabetes Foundation  Hong Kong SAR"},{"name":"Hong Kong Institute of Diabetes and Obesity The Chinese University of Hong Kong, Prince of Wales Hospital  Shatin Hong Kong SAR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1305-1598","authenticated-orcid":false,"given":"Linong","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Peking University People's Hospital  Peking China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. G.","family":"Unnikrishnan","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Chellaram Diabetes Institute  Pune Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sirinart","family":"Sirinvaravong","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine Siriraj Hospital Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siew\u2010Pheng","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine University Malaya  Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4137-1671","authenticated-orcid":false,"given":"Soo","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Bundang Hospital, Seoul National University College of Medicine  Seongnam South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5244-6069","authenticated-orcid":false,"given":"Andrea O. 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