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However, to date studies have not defined optimal treatment of hyperglycaemia associated with glucocorticoids and this is reflected in clinical guidelines. We recently reported the large range in the daily insulin dose requirements in hospitalized patients prescribed glucocorticoids. Failure to rapidly and accurately approximate the required insulin dose is a likely explanation for the suboptimal glycaemic control commonly reported in glucocorticoid\u2010treated patients. Body weight is usually used to calculate insulin doses; while it is associated with the calculated daily insulin dose in patients on glucocorticoids, it only explains a small proportion of dosing variance. However, other clinical factors, such as sex, presence or absence of known diabetes, glucose\u2010lowering treatment before hospital admission and glycosylated haemoglobin are also associated with the insulin dose requirements in patients with hyperglycaemia on glucocorticoids. We hypothesize that incorporation of additional clinical factors into insulin dosing calculations could potentially facilitate individualized treatment and improve outcomes for hospitalized patients with hyperglycaemia while prescribed glucocorticoids.<\/jats:p>","DOI":"10.1111\/dom.70756","type":"journal-article","created":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T09:28:46Z","timestamp":1776072526000},"page":"5455-5462","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Glucocorticoid\u2010Induced Hyperglycaemia in Hospital: The Insulin Dose Matters Most"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6468-7727","authenticated-orcid":false,"given":"Morton G.","family":"Burt","sequence":"first","affiliation":[{"name":"Department of Endocrinology Flinders Medical Centre  Bedford Park Australia"},{"name":"College of Medicine and Public Health Flinders University  Bedford Park Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faran","family":"Khalili","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Flinders Medical Centre  Bedford Park Australia"},{"name":"College of Medicine and Public Health Flinders University  Bedford Park Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjana","family":"Radhakutty","sequence":"additional","affiliation":[{"name":"Department of Medicine Lyell McEwin Hospital  Elizabeth Vale Australia"},{"name":"Faculty of Medicine and Health Sciences University of Adelaide  Adelaide Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5760-939X","authenticated-orcid":false,"given":"Angela X.","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Flinders Medical Centre  Bedford Park Australia"},{"name":"College of Medicine and Public Health Flinders University  Bedford Park Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,13]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.87.3.8341"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.4065\/78.12.1471"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2005.051029"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)08415-9"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/hs1001.096194"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000004133"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-1407"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc18\u20102342"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc23\u20101905"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2013.01.026"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-2729"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2011.04242.x"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE\u201018\u20100315"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.3803\/EnM.2024.1951"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1055\/a\u20102661\u20105208"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eprac.2026.01.024"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.7861\/clinmedicine.14\u20103\u2010326a"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00654.2005"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12045"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2012.12.023"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40842\u2010023\u201000158\u20101"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9124079"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.16378"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1204942"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13195801"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-2098"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgac278"},{"key":"e_1_2_14_29_1","unstructured":"D.Chipps B.Depczynski K.Heels et\u00a0al. \u201cAustralian Diabetes Society Guidelines for Routine Glucose Control in Hospital\u201d(2012) https:\/\/www.diabetessociety.com.au\/documents\/ADSGuidelinesforRoutineGlucoseControlinHospitalFinal2012.pdf."},{"key":"e_1_2_14_30_1","unstructured":"G. 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