{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:58:00Z","timestamp":1786121880626,"version":"build-2736575974"},"reference-count":46,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100019063","name":"Tandem Diabetes Care","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019063","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Automated insulin delivery (AID) has been established as an effective therapy for individuals with type 1 diabetes. This analysis evaluates the clinical and economic outcomes of AID compared with multiple daily injections plus continuous glucose monitoring (MDI\/CGM) in adults with type 2 diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>The IQVIA CORE Diabetes Model v10.0 was employed to simulate the impact of using the t:slim X2 insulin pump with Control\u2010IQ+ technology (Control\u2010IQ+) versus MDI\/CGM over a 50\u2010year period using data from the 2IQP randomized controlled trial (NCT05785832). Trial data informed cohort demographics, intervention effects and resource utilization while literature sources provided health state utilities and costs. Scenario analyses examined the effect of Control\u2010IQ+ on reducing HbA1c based on alternative HbA1c progression estimates from the Swedish National Diabetes Registry and alternative resource use and treatment effects from real\u2010world evidence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The base case analysis indicated that direct medical costs per individual for type 2 diabetes management with Control\u2010IQ+ were $239\u2009935 compared to $209\u2009792 with MDI\/CGM use. Control\u2010IQ+ resulted in 0.51 additional quality\u2010adjusted life years (QALYs: 10.36 vs. 9.85 for MDI\/CGM), yielding an incremental cost\u2010effectiveness ratio (ICER) of $59\u2009417 per QALY, 95% CI: ($55\u2009836, $62\u2009998). In probabilistic sensitivity analyses, 89% of simulations produced ICERs below $100\u2009000\/QALY. ICERs across all scenarios remained below $100\u2009000 per QALY.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Control\u2010IQ+ is associated with increased life expectancy, higher QALYs and reduced complication rates. These findings suggest that Control\u2010IQ+ is cost\u2010effective relative to MDI\/CGM for managing patients with type 2 diabetes in the United States.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.70759","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:29:43Z","timestamp":1778027383000},"page":"6280-6290","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cost\u2010Effectiveness of Control\u2010\n                    <scp>IQ<\/scp>\n                    + Technology in Insulin\u2010Treated Patients With Type 2 Diabetes in the United States"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-6840-3360","authenticated-orcid":false,"given":"Neda","family":"Al Rawashdh","sequence":"first","affiliation":[{"name":"IQVIA Real\u2010World Evidence Solutions  Falls Church Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bimal V.","family":"Patel","sequence":"additional","affiliation":[{"name":"Tandem Diabetes Care  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon M.","family":"Wang","sequence":"additional","affiliation":[{"name":"Tandem Diabetes Care  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard M.","family":"Zur","sequence":"additional","affiliation":[{"name":"IQVIA Real\u2010World Evidence Solutions  Falls Church Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Anaya","sequence":"additional","affiliation":[{"name":"IQVIA Real\u2010World Evidence Solutions  Falls Church Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily B.","family":"Kahn","sequence":"additional","affiliation":[{"name":"IQVIA Real\u2010World Evidence Solutions  Falls Church Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan E.","family":"Pinsker","sequence":"additional","affiliation":[{"name":"Tandem Diabetes Care  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravid","family":"Sasson\u2010Katchalski","sequence":"additional","affiliation":[{"name":"Tandem Diabetes Care  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex C.","family":"Trahan","sequence":"additional","affiliation":[{"name":"Tandem Diabetes Care  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7493-0989","authenticated-orcid":false,"given":"Laurel H.","family":"Messer","sequence":"additional","affiliation":[{"name":"Tandem Diabetes Care  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimia","family":"Assadi","sequence":"additional","affiliation":[{"name":"Tandem 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