{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:55:15Z","timestamp":1787241315496,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T00:00:00Z","timestamp":1776038400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T00:00:00Z","timestamp":1776038400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Metabolic dysfunction\u2013associated steatotic liver disease is common among individuals with type 2 diabetes mellitus and substantially increases the risk of liver cirrhosis and hepatocellular carcinoma. Effective therapies that improve metabolic control while preventing advanced liver outcomes are limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To evaluate the association between semaglutide treatment and the risk of liver cirrhosis and hepatocellular carcinoma in adults with type 2 diabetes mellitus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a retrospective population\u2010based cohort study using electronic health records from a large integrated healthcare organization. Adults with type 2 diabetes mellitus and no prior diagnosis of liver cirrhosis or hepatocellular carcinoma were included. Exposure was defined as treatment with semaglutide for at least four consecutive months compared with matched control patients. Cox proportional hazards models estimated adjusted hazard ratios with 95% confidence intervals, accounting for demographic factors, body mass index, smoking status, glycaemic control, other antidiabetic treatments and baseline liver fibrosis risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 71\u2009612 individuals, 35\u2009806 received semaglutide and 35\u2009806 were matched controls. Over a median follow\u2010up of 4628\u2009days for liver cirrhosis and 4090\u2009days for HCC, 245 patients developed liver cirrhosis and 21 developed hepatocellular carcinomas. In the Cox model, there was no association between semaglutide treatment and the diagnosis of liver cirrhosis (HR 1.3, 95% CI 0.98\u20131.77) or hepatocellular carcinoma (HR 0.6, 95% CI 0.21\u20131.51).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this real\u2010world study, semaglutide treatment was not associated with a reduced risk of liver cirrhosis or hepatocellular carcinoma among adults with type 2 diabetes mellitus.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.70763","type":"journal-article","created":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T09:30:48Z","timestamp":1776072648000},"page":"5704-5714","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Association of Semaglutide Treatment With Liver Cirrhosis and Hepatocellular Carcinoma in Type 2 Diabetes: A Population\u2010Based Cohort Study"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7004-7897","authenticated-orcid":false,"given":"Assaf","family":"Issachar","sequence":"first","affiliation":[{"name":"Liver Institute, Rabin Medical Center Beilinson Hospital  Petah Tikva Israel"},{"name":"Gray School of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2172-1044","authenticated-orcid":false,"given":"Talish","family":"Razi","sequence":"additional","affiliation":[{"name":"Community Medical Services Division Clalit Health Services  Tel Aviv Israel"},{"name":"School of Industrial and Intelligent System Engineering Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilya","family":"Borochov","sequence":"additional","affiliation":[{"name":"Community Medical Services Division Clalit Health Services  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1721-1360","authenticated-orcid":false,"given":"Hadar","family":"Duskin Bitan","sequence":"additional","affiliation":[{"name":"Gray School of Medicine Tel Aviv University  Tel Aviv Israel"},{"name":"Community Medical Services Division Clalit Health Services  Tel Aviv Israel"},{"name":"Institute of Endocrinology, Rabin Medical Center Beilinson Hospital  Petah Tikva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6058-8665","authenticated-orcid":false,"given":"Ronen","family":"Arbel","sequence":"additional","affiliation":[{"name":"Community Medical Services Division Clalit Health Services  Tel Aviv Israel"},{"name":"Maximizing Health Outcomes Research Lab Sapir College  Sderot Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.04.036"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(22)00003-1"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.16752"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.13663"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaf336"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-01663-y"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0289616"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.769069"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2413258"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2307563"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/endrev\/bnac018"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000003760"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.15437"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-024-10752-9"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.15898"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2024.1096"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2024.4661"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2024.04.029"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.13751"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-023-03228-4"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.17925"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1198871"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-021-07341-z"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.08.030"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.17037"}],"container-title":["Diabetes, 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