{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:58:46Z","timestamp":1786121926011,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Type 1 diabetes is a chronic autoimmune disease characterised by progressive pancreatic \u03b2\u2010cell destruction and the early appearance of islet autoantibodies (islet\u2010AAb) during the pre\u2010symptomatic phases. Given the growing interest in screening and prevention of type 1 diabetes, this study aimed to assess the prevalence of pancreatic autoimmunity in adults with other organ\u2010specific autoantibodies in order to identify potential target populations for screening programs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Adults previously tested for autoantibodies against specific endocrine glands and\/or gastric parietal cells by indirect immunofluorescence were divided into two groups (Autoimmunity group and Control group), according to the presence of at least one organ\u2010specific autoantibody. Stored serum samples from all participants were re\u2010evaluated for islet\u2010AAb and comparisons were performed between groups and, within the Autoimmunity group (Group A), across different patterns of organ\u2010specific autoimmunity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Positivity for at least one islet\u2010AAb was significantly higher in Group A than in Control Group (40.3% vs. 21.0%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.007). Double and triple islet\u2010AAb positivity were less common overall, but occurred more frequently in Group A. Moreover, in Group A, a significantly higher prevalence of multiple positivity (\u2265\u20092 islet\u2010AAb) was observed in subjects with ovarian autoimmunity and in those with combined pituitary and ovarian autoimmunity than in those with other endocrine autoimmune involvement.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Adults with specific autoimmunity disorders, particularly those affecting ovarian and\/or pituitary glands, have a higher prevalence of pancreatic autoimmunity. These subjects may benefit from targeted screening to identify the pre\u2010symptomatic stage of T1D and potentially delay progression to clinical disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.70776","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T08:22:34Z","timestamp":1776673354000},"page":"5827-5833","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Islet Autoantibodies in Adult With Pituitary and Ovarian Autoimmunity: Implications for Type 1 Diabetes Screening"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4748-321X","authenticated-orcid":false,"given":"Giuseppe","family":"Bellastella","sequence":"first","affiliation":[{"name":"Unit of Endocrinology and Metabolic Diseases AOU University of Campania \u201cLuigi Vanvitelli\u201d  Naples Italy"},{"name":"Department of Advanced Medical and Surgical Sciences University of Campania \u201cLuigi Vanvitelli\u201d  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela","family":"di Nuzzo","sequence":"additional","affiliation":[{"name":"Department of Advanced Medical and Surgical Sciences University of Campania \u201cLuigi Vanvitelli\u201d  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6459-5854","authenticated-orcid":false,"given":"Miriam","family":"Longo","sequence":"additional","affiliation":[{"name":"Department of Advanced Medical and Surgical Sciences University of Campania \u201cLuigi Vanvitelli\u201d  Naples Italy"},{"name":"Department of Life Science, Health, and Health Professions Link Campus University  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Cirillo","sequence":"additional","affiliation":[{"name":"Department of Advanced Medical and Surgical Sciences University of Campania \u201cLuigi Vanvitelli\u201d  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonietta","family":"Maio","sequence":"additional","affiliation":[{"name":"Department of Advanced Medical and Surgical Sciences University of Campania \u201cLuigi Vanvitelli\u201d  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Di Martino","sequence":"additional","affiliation":[{"name":"Department of Advanced Medical and Surgical Sciences University of Campania \u201cLuigi Vanvitelli\u201d  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Angelino","sequence":"additional","affiliation":[{"name":"Unit of Endocrinology and Metabolic Diseases AOU University of Campania \u201cLuigi Vanvitelli\u201d  Naples Italy"},{"name":"Department of Advanced Medical and Surgical Sciences University of Campania \u201cLuigi Vanvitelli\u201d  Naples 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