{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T05:24:28Z","timestamp":1792905868204,"version":"4.5.0"},"reference-count":44,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK\u2010120331"],"award-info":[{"award-number":["DK\u2010120331"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Metabolic dysfunction\u2010associated steatohepatitis (MASH) is a leading cause of cirrhosis. NIS2+\u2009is a recently approved serum\u2010based test combining two biomarkers (miR\u201034a\u20105p and YKL\u201040) to identify at\u2010risk MASH (i.e., MASH and significant fibrosis).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the prevalence of at\u2010risk MASH by NIS2+\u2009in individuals from primary care or endocrinology clinics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>798 participants recruited from outpatient clinics were risk\u2010stratified by NIS2+ into low\u2010risk, intermediate\u2010risk or having at\u2010risk MASH (NIS2+ score &lt;\u20090.46, \u2265\u20090.46 and &lt;\u20090.68 or \u2265\u20090.68, respectively). Presence of steatosis (CAP\u2009\u2265\u2009288\u2009dB\/m) and clinically significant liver fibrosis (VCTE\u2010\u2009\u2265\u20098.0\u2009kPa) was established by transient elastography (FibroScan).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At\u2010risk MASH affected 29% of individuals with both obesity and T2D compared to 3% of those without either condition (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). People with at\u2010risk MASH, compared to those at low\u2010risk, more often had steatosis (81% vs. 40%), clinically significant fibrosis (42% vs. 5%), AST or ALT \u2265\u200940\u2009IU\/L, hepatic insulin resistance (by HOMA\u2010IR) and adipose tissue insulin resistance (by adipo\u2010IR) (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). NIS2+\u2009strongly correlated with diagnosis of at\u2010risk MASH by FAST (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.67;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), as well as CK\u201018, ALT and AST and liver fibrosis by VCTE\u2010LSM (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The prevalence of at\u2010risk MASH is high in individuals with obesity and T2D attending outpatient primary care and endocrinology clinics. Their progression to cirrhosis may be prevented with early risk\u2010stratification and timely intervention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.70799","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T03:10:03Z","timestamp":1777518603000},"page":"6184-6193","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["High Prevalence of Metabolic Dysfunction\u2013Associated Steatohepatitis With Significant Fibrosis in Primary Care and Endocrinology Clinics"],"prefix":"10.1111","volume":"28","author":[{"given":"Srilaxmi","family":"Kalavalapalli","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolism Department of Medicine, University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eddison Godinez","family":"Leiva","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolism Department of Medicine, University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea Ortiz","family":"Rocha","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolism Department of Medicine, University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anu","family":"Sharma","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolism Department of Medicine, University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Barb","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolism Department of Medicine, University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathaly","family":"Cuervo\u2010Pardo","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolism Department of Medicine, University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly Y.","family":"Chun","sequence":"additional","affiliation":[{"name":"Labcorp  Calabasas California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toni R.","family":"Prezant","sequence":"additional","affiliation":[{"name":"Labcorp  Calabasas California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margery A.","family":"Connelly","sequence":"additional","affiliation":[{"name":"Labcorp  Morrisville North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens T.","family":"Rosenberg","sequence":"additional","affiliation":[{"name":"Advanced Magnetic Resonance Imaging and 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