{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:58:00Z","timestamp":1786121880843,"version":"build-2736575974"},"reference-count":54,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T00:00:00Z","timestamp":1776816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T00:00:00Z","timestamp":1776816000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Forschung, Technologie und Raumfahrt","doi-asserted-by":"publisher","award":["01GI0925"],"award-info":[{"award-number":["01GI0925"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Elevated fasting glucagon is linked to hyperglycemia, but postprandial glucagon effects are less understood. Recent evidence suggests metabolic benefits of rising glucagon after oral glucose intake, potentially impacting brain\u2010mediated whole\u2010body metabolism. To elucidate the translational relevance of these findings, we studied postprandial effects of glucagon on the human brain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>We performed oral glucose tolerance tests (OGTT) combined with functional magnetic resonance imaging to quantify brain activity and connectivity at fasting, 30 and 120\u2009min post glucose load in 30 volunteers. In 14 participants with suppressed glucagon, low\u2010dose glucagon infusion mimicked non\u2010suppressed glucagon after OGTT. This was compared to 7 participants with endogenous rising glucagon during OGTT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Low\u2010dose glucagon infusion did not elevate plasma glucose levels during OGTT. Also, no changes in insulin sensitivity and insulin secretion were observed. However, experimentally elevating glucagon during OGTT in individuals with physiological suppression of glucagon significantly increased postprandial brain responsivity in the hippocampal gyrus and in brain regions important for the homeostatic and hedonic regulation of food intake as well as systemic metabolism (i.e., hypothalamus and ventral striatum). Most postprandial brain responsiveness during glucagon infusion was directionally consistent with the findings in persons with endogenously rising glucagon. Moreover, the postprandial brain response correlated with the rise in glucagon, regardless of exogenous or endogenous source of glucagon. Although the overall glucagon trajectory during OGTT was not significantly different over the full 0\u2013150\u2009min period, the groups differed at key post\u2010challenge timepoints and in integrated glucagon exposure. Together with the infusion and correlation analyses, this supports a relationship between postprandial glucagon and brain responsivity, while more subtle differences in glucagon kinetics will require larger studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings demonstrate postprandial effects of glucagon in metabolically relevant human brain areas. This may underlie the promising effects on body weight achieved with pharmacological multi\u2010agonists that activate the glucagon receptor.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.70801","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T09:19:42Z","timestamp":1776849582000},"page":"5926-5938","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Postprandial Glucagon Action in the Human Brain"],"prefix":"10.1111","volume":"28","author":[{"given":"Robert","family":"Wagner","sequence":"first","affiliation":[{"name":"Institute for Clinical Diabetology, German Diabetes Center, Leibnitz Center for Diabetes Research at Heinrich Heine University D\u00fcsseldorf  D\u00fcsseldorf Germany"},{"name":"German Center for Diabetes Research (DZD e.V.)  Neuherberg Germany"},{"name":"Department of Endocrinology and Diabetology Medical Faculty and University Hospital D\u00fcsseldorf, Heinrich Heine University D\u00fcsseldorf  D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Kullmann","sequence":"additional","affiliation":[{"name":"German Center for Diabetes Research (DZD e.V.)  Neuherberg Germany"},{"name":"Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of T\u00fcbingen  T\u00fcbingen Germany"},{"name":"Department of Internal Medicine IV, Division of Diabetology, Endocrinology and Nephrology Eberhard Karls University T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Hummel","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetology, Department of Internal Medicine I University of Ulm  Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsiaryna","family":"Prystupa","sequence":"additional","affiliation":[{"name":"Institute for Clinical Diabetology, German Diabetes Center, Leibnitz Center for Diabetes Research at Heinrich Heine University D\u00fcsseldorf  D\u00fcsseldorf Germany"},{"name":"German Center for Diabetes Research (DZD e.V.)  Neuherberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Hosenfeld","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine IV, Division of Diabetology, Endocrinology and Nephrology Eberhard Karls University T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Veit","sequence":"additional","affiliation":[{"name":"German Center for Diabetes Research (DZD e.V.)  Neuherberg Germany"},{"name":"Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1407-9023","authenticated-orcid":false,"given":"Andreas L.","family":"Birkenfeld","sequence":"additional","affiliation":[{"name":"German Center for Diabetes Research (DZD e.V.)  Neuherberg Germany"},{"name":"Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of T\u00fcbingen  T\u00fcbingen Germany"},{"name":"Department of Internal Medicine IV, Division of Diabetology, Endocrinology and Nephrology Eberhard Karls University T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans\u2010Ulrich","family":"H\u00e4ring","sequence":"additional","affiliation":[{"name":"German Center for Diabetes Research (DZD e.V.)  Neuherberg Germany"},{"name":"Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of T\u00fcbingen  T\u00fcbingen Germany"},{"name":"Department of Internal Medicine IV, Division of Diabetology, Endocrinology and Nephrology Eberhard Karls University T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hubert","family":"Preissl","sequence":"additional","affiliation":[{"name":"German Center for Diabetes Research (DZD e.V.)  Neuherberg Germany"},{"name":"Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of T\u00fcbingen  T\u00fcbingen Germany"},{"name":"Department of Internal Medicine IV, Division of Diabetology, Endocrinology and Nephrology Eberhard Karls University T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Fritsche","sequence":"additional","affiliation":[{"name":"German Center for Diabetes Research (DZD e.V.)  Neuherberg Germany"},{"name":"Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of T\u00fcbingen  T\u00fcbingen Germany"},{"name":"Department of Internal Medicine IV, Division of Diabetology, Endocrinology and Nephrology Eberhard Karls University T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Peter","sequence":"additional","affiliation":[{"name":"German Center for Diabetes Research (DZD e.V.)  Neuherberg Germany"},{"name":"Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of T\u00fcbingen  T\u00fcbingen Germany"},{"name":"Institute for Clinical Chemistry and Pathobiochemistry, Department for Diagnostic Laboratory Medicine University Hospital T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8462-3832","authenticated-orcid":false,"given":"Martin","family":"Heni","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetology, Department of Internal Medicine I University of Ulm  Ulm Germany"},{"name":"Institute for Clinical Chemistry and Pathobiochemistry, Department for Diagnostic Laboratory Medicine University Hospital T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,22]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00025.2016"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2008.09.008"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010020\u20102074\u20106"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.2337\/db22\u20100313"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2018\u201000251"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.2337\/db16\u20100354"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE\u201022\u20100291"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2011\u20101979"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2017.03.019"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198504113121519"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.14.4368"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1210\/jendso\/bvaf056"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740\u20100929.2009.00685.x"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125\u2010016\u20103950\u20103"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213\u20108587(20)30113\u20103"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125\u2010024\u201006104\u20109"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010020\u201015686\u2010y"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.209"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2020.101090"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010020\u20101116\u20109"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.892677"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.2337\/db14\u20100242"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.22.9.1462"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjdrc\u20102022\u2010002909"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2017\u201001976"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22243"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1109\/TSP.2008.2005752"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25197"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.108.097618"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2019.116189"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125\u2010023\u201005947\u2010y"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOL.0000000000000857"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2016.02.002"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.13745"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2014.10.023"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11892\u2010006\u20100033\u20108"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.2337\/db16\u20101380"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1159\/000504551"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125\u2010020\u201005204\u20106"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463\u20101326.2011.01453.x"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2017.03.036"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abl7398"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572\u2010022\u201000351\u2010z"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20163905"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2015.09.014"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3115"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20220940"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2015.10.049"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a021691"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2023.101470"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2010.08.002"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0000000000000874"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.15448"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574\u2010018\u20100118\u2010x"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dom-pubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dom.70801","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/dom.70801","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dom.70801","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T07:33:55Z","timestamp":1786088035000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.onlinelibrary.wiley.com\/doi\/10.1111\/dom.70801"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,22]]},"references-count":54,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1111\/dom.70801"],"URL":"https:\/\/doi.org\/10.1111\/dom.70801","archive":["Portico"],"relation":{},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"value":"1462-8902","type":"print"},{"value":"1463-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,22]]},"assertion":[{"value":"2026-01-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}