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Although considered the gold standard, the euglycemic\u2010hyperinsulinemic clamp evaluates insulin sensitivity under non\u2010physiological conditions and is highly burdensome and costly, thereby prompting the development of alternative methods. The 24\u2010h urinary C\u2010peptide excretion rate adjusted for energy intake is a surrogate marker of insulin sensitivity in non\u2010diabetic adults. We hypothesized that the combination of 24\u2010h continuous glucose monitoring (CGM) and 24\u2010h urinary C\u2010peptide excretion (24\u2009h\u2010glycemia\/C\u2010peptide ratio) would be a better predictor of insulin sensitivity than the C\u2010peptide excretion rate adjusted for energy intake or other widely accepted indexes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Thirteen non\u2010diabetic individuals (7 women, 6 men; 52.2\u2009\u00b1\u200913.8\u2009years; BMI: 26.1\u2009\u00b1\u20093.7\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ) participated in this cross\u2010sectional study. They completed a 24\u2010h stay in a whole\u2010room indirect calorimeter wearing a CGM sensor (Dexcom G6 Pro) while all produced urine was collected. Insulin sensitivity was assessed by a 2\u2010step hyperinsulinemic\u2010euglycemic clamp [180\u2009min at 10\u2009mU\/min\/m\n                      <jats:sup>2<\/jats:sup>\n                      (low\u2010dose) and 120\u2009min at 80\u2009mU\/min\/m\n                      <jats:sup>2<\/jats:sup>\n                      (high\u2010dose)].\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The 24\u2009h\u2010glycemia\/C\u2010peptide ratio was positively associated with the clamp's low\u2010dose glucose infusion rate (GIR:\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.401,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.020) and tended to be associated with the high\u2010dose GIR (\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.266,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.086). The associations between GIR and previously accepted markers of insulin sensitivity resulted in\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      ranging from 0.248 to 0.456 for the clamp low dose and\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      ranging from 0.108 to 0.174 for the clamp high dose.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These results suggest that the 24\u2009h\u2010glycemia\/C\u2010peptide ratio is a promising simple, inexpensive, non\u2010invasive, and physiological marker of insulin sensitivity that deserves further investigation.<\/jats:p>\n                  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Nutrici\u00f3n (CIBEROBN), Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kara L.","family":"Marlatt","sequence":"additional","affiliation":[{"name":"Pennington Biomedical Research Center  Baton Rouge Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robbie A.","family":"Beyl","sequence":"additional","affiliation":[{"name":"Pennington Biomedical Research Center  Baton Rouge Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua R.","family":"Sparks","sequence":"additional","affiliation":[{"name":"Pennington Biomedical Research Center  Baton Rouge Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily W.","family":"Flanagan","sequence":"additional","affiliation":[{"name":"Pennington Biomedical Research Center  Baton Rouge Louisiana 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