{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T01:50:38Z","timestamp":1789091438461,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:00:00Z","timestamp":1776902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:00:00Z","timestamp":1776902400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32371234"],"award-info":[{"award-number":["32371234"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin Municipality","doi-asserted-by":"publisher","award":["24JCZDJC00890"],"award-info":[{"award-number":["24JCZDJC00890"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2019YFA0802503"],"award-info":[{"award-number":["2019YFA0802503"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFA1802704"],"award-info":[{"award-number":["2024YFA1802704"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Early\u2010life environmental exposures, including nutritional supply, can influence health in adulthood. Leucine, isoleucine, and valine are collectively known as branched\u2010chain amino acids (BCAAs). While BCAAs are essential nutrients, their elevated abundances in adults have been tightly associated with metabolic disorders. However, whether excessive intake of BCAAs in early life affects the metabolic dysfunctions in adult life remains unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p>Continuous BCAAs supplementation in drinking water throughout gestation, lactation, and early\u2010juvenile period reduced body weight, decreased fat mass and improved glucose homeostasis in adult male mice challenged with a high\u2010fat diet (HFD) starting at 6\u2009weeks of age. Lactational BCAAs supplementation alone partially recapitulated these beneficial metabolic effects, resulting in decreased body weight and improved insulin tolerance, whereas gestational or early\u2010juvenile exposure showed no significant metabolic impacts in adult males. Analysis of individual BCAA supplementation during lactation period showed that leucine, isoleucine, and valine demonstrated either beneficial or detrimental impacts on obesity, insulin resistance, and fatty liver in adult male mice, respectively. In females, lactational supplementation of individual BCAA produced distinct effects compared with males.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Excessive BCAAs exposure during developmental stages, particularly the lactation period, shows pronounced effects on male adult metabolic dysfunction. Moreover, supplementation with individual BCAA during lactation exerts distinct and sexually dimorphic effects on adult metabolic health. These results highlight the potential of early\u2010life precision nutrition strategies to mitigate metabolic dysfunction later in life.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.70809","type":"journal-article","created":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T09:11:37Z","timestamp":1776935497000},"page":"6009-6021","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Sexually Dimorphic Impacts of Early Life\n                    <scp>BCAAs<\/scp>\n                    Supplementation on Metabolic Dysfunctions in Adult Mice"],"prefix":"10.1111","volume":"28","author":[{"given":"Qianqian","family":"Yue","sequence":"first","affiliation":[{"name":"NHC Key Lab of Hormones and Development and Tianjin Key Lab of Metabolic Diseases Tianjin Medical University Chu Hsien\u2010I Memorial Hospital &amp; Institute of Endocrinology  Tianjin China"},{"name":"Department of Physiology and Pathophysiology Tianjin Medical University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6887-2410","authenticated-orcid":false,"given":"Lulu","family":"Zhang","sequence":"additional","affiliation":[{"name":"NHC Key Lab of Hormones and Development and Tianjin Key Lab of Metabolic Diseases Tianjin Medical University Chu Hsien\u2010I Memorial Hospital &amp; Institute of Endocrinology  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruihang","family":"Wang","sequence":"additional","affiliation":[{"name":"NHC Key Lab of Hormones and Development and Tianjin Key Lab of Metabolic Diseases Tianjin Medical University Chu Hsien\u2010I Memorial Hospital &amp; Institute of Endocrinology  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longfei","family":"Cui","sequence":"additional","affiliation":[{"name":"NHC Key Lab of Hormones and Development and Tianjin Key Lab of Metabolic Diseases Tianjin Medical University Chu Hsien\u2010I Memorial Hospital &amp; Institute of Endocrinology  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Pei","sequence":"additional","affiliation":[{"name":"NHC Key Lab of Hormones and Development and Tianjin Key Lab of Metabolic Diseases Tianjin Medical University Chu Hsien\u2010I Memorial Hospital &amp; Institute of Endocrinology  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maosen","family":"Zhang","sequence":"additional","affiliation":[{"name":"NHC Key Lab of Hormones and Development and Tianjin Key Lab of Metabolic Diseases Tianjin Medical University Chu Hsien\u2010I Memorial Hospital &amp; Institute of Endocrinology  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunjiong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology Tianjin Medical University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caiyun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, 903rd Hospital of PLA  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2128-3209","authenticated-orcid":false,"given":"Haipeng","family":"Sun","sequence":"additional","affiliation":[{"name":"NHC Key Lab of Hormones and Development and Tianjin Key Lab of Metabolic Diseases Tianjin Medical University Chu Hsien\u2010I Memorial Hospital &amp; Institute of Endocrinology  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiping J.","family":"Zhang","sequence":"additional","affiliation":[{"name":"NHC Key Lab of Hormones and Development and Tianjin Key Lab of Metabolic Diseases Tianjin Medical University Chu Hsien\u2010I Memorial Hospital &amp; Institute of Endocrinology  Tianjin China"},{"name":"Department of Pathophysiology Naval Medical University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3983-8168","authenticated-orcid":false,"given":"Xuejiao","family":"Zhang","sequence":"additional","affiliation":[{"name":"NHC Key Lab of Hormones and Development and Tianjin Key Lab of Metabolic Diseases Tianjin Medical University Chu Hsien\u2010I Memorial Hospital &amp; Institute of Endocrinology  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2015-1394"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.14811"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2010.12.011"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1017\/S2040174420000318"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.113.02671"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11010096"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12020315"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.115.216465"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.2337\/db19-0920"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.2337\/db18-0927"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15010068"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-022-00760-3"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-020518-114455"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-023-05985-6"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2023.102696"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.119.043581"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202000195R"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43856-023-00382-x"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2021.03.025"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-020-00006-2"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2014.171"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-019-05040-3"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe058187"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2024.217006"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.ade1662"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dom-pubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dom.70809","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/dom.70809","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dom.70809","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T07:34:15Z","timestamp":1786088055000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.onlinelibrary.wiley.com\/doi\/10.1111\/dom.70809"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,23]]},"references-count":25,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1111\/dom.70809"],"URL":"https:\/\/doi.org\/10.1111\/dom.70809","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/DOM.70809\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.70809\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.70809\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.70809\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.70809\/v1\/review4","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.70809\/v1\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.70809\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.70809\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.70809\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.70809\/v1\/review1","asserted-by":"object"}]},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"value":"1462-8902","type":"print"},{"value":"1463-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,23]]},"assertion":[{"value":"2026-01-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}