{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:17:39Z","timestamp":1789172259657,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270676"],"award-info":[{"award-number":["82270676"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To investigate the associations between intrapancreatic fat deposition (IPFD), quantified by the pancreas\u2013spleen attenuation difference (P\u2013S Difference) on non\u2010enhanced computed tomography (CT), and metabolic biomarkers in Chinese adults, and to distinguish direct and indirect effects of IPFD via body mass index (BMI) and metabolic dysfunction\u2010associated steatotic liver disease (MASLD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>This single\u2010centre, retrospective study analysed 558 Chinese adults (mean age 63.8\u2009\u00b1\u200913.6\u2009years; 44.4% male). IPFD was quantified as the P\u2013S Difference; lower values indicated greater IPFD. Missing data were handled by multiple imputation. Sequentially adjusted multivariable regression, restricted cubic splines, directed acyclic graph\u2010informed mediation, and stratified analyses were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In the fully adjusted model, lower P\u2013S Difference was independently associated with higher fasting plasma glucose (FPG; \u03b2\u2009=\u2009\u22120.0068, 95% CI \u22120.0136 to 0.0000;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.049), triglycerides (TG; \u03b2\u2009=\u2009\u22120.0023, [\u22120.0043 to \u22120.0002];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.028), free fatty acids (FFA; \u03b2\u2009=\u2009\u22120.0012, [\u22120.0021 to \u22120.0003];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.012), and triglyceride glucose (TyG) index (\u03b2\u2009=\u2009\u22120.0028, [\u22120.0046 to \u22120.0010];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002), and with lower high\u2010density lipoprotein cholesterol (HDL\u2010C; \u03b2\u2009=\u20090.0013, [0.0002 to 0.0024];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.025). Associations with clinical diagnoses (hypertension, metabolic syndrome, type 2 diabetes and coronary heart disease) were non\u2010significant after adjustment. BMI mediated \u2264\u20097.1% of associations, whereas MASLD partially mediated TG (22.5%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.017) and TyG (15.7%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.019).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>IPFD was associated with an early metabolic signature, notably elevated TG, FFA, and TyG, independent of BMI and MASLD. Prospective validation is required.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.70875","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T05:45:36Z","timestamp":1778651136000},"page":"6776-6786","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Intrapancreatic Fat Deposition and Metabolic Signatures Across Adiposity Phenotypes in Chinese Adults: A Computed Tomography Analysis"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-9081-0766","authenticated-orcid":false,"given":"Wenlu","family":"Zong","sequence":"first","affiliation":[{"name":"The Affiliated Hospital of Qingdao University  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqing","family":"Yu","sequence":"additional","affiliation":[{"name":"The Affiliated Hospital of Qingdao University  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Affiliated Hospital of Qingdao University  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Jiang","sequence":"additional","affiliation":[{"name":"The Affiliated Hospital of Qingdao University  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pin","family":"Meng","sequence":"additional","affiliation":[{"name":"The Affiliated Hospital of Qingdao University  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zibin","family":"Tian","sequence":"additional","affiliation":[{"name":"The Affiliated Hospital of Qingdao University  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guotao","family":"Lu","sequence":"additional","affiliation":[{"name":"Pancreatic Center, Department of Gastroenterology, Yangzhou Key Laboratory of Pancreatic Disease The Affiliated Hospital of Yangzhou University, Yangzhou University  Yangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Li","sequence":"additional","affiliation":[{"name":"The Affiliated Hospital of Qingdao University  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,12]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-024-01008-5"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12071"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2016.12.012"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-021-00551-0"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(84)80294-4"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc07-0326"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.113.000297"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.15140446"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20180267"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.13122883"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2019.12.017"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61602-X"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29367"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.28098"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.2307\/2529310"},{"key":"e_1_2_11_17_1","first-page":"83","article-title":"Predictive Values of Body Mass Index and Waist Circumference for Risk Factors of Certain Related Diseases in Chinese Adults\u2013Study on Optimal Cut\u2010Off Points of Body Mass Index and Waist Circumference in Chinese Adults","volume":"15","author":"Zhou B. 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