{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:15:03Z","timestamp":1789172103102,"version":"build-2803163510"},"reference-count":55,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Purpose<\/jats:title>\n                    <jats:p>Using the clinical obesity concept recently proposed by the Lancet Diabetes &amp; Endocrinology Commission, this study evaluated the impact of clinical obesity on new\u2010onset atrial fibrillation (AF) in the general population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Individuals who underwent first health examinations from June 2006 to October 2007 in Kailuan were included. Based on body mass index (BMI), waist circumference (WC), waist\u2010to\u2010height ratio (WHtR), waist\u2010to\u2010hip ratio (WHR), and presence of obesity\u2010related organ\/tissue dysfunction, participants were divided into no obesity, preclinical obesity, and clinical obesity groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 98\u2009730 participants free from AF at baseline were identified. Of these, 1343 developed new\u2010onset AF over a median follow\u2010up of 16.97\u2009years. The AF incidence densities were 0.67, 0.68, and 1.25 per 1000 person\u2010years in the no obesity, preclinical, and clinical obesity groups, respectively. Compared to the no obesity group, the clinical obesity (HR: 1.29, 95% CI: 1.12\u20131.47) group showed increased risks of new\u2010onset AF. Clinical obesity remained associated with higher new\u2010onset AF risk in participants aged &lt;\u200945\u2009years (HR: 2.34, 95% CI: 1.42\u20133.86) and 45\u2010\u2009&lt;\u200960\u2009years (HR: 1.40, 95% CI: 1.14\u20131.71). In men, clinical obesity was associated with 35% higher risks of new\u2010onset AF (HR: 1.34, 95% CI: 1.16\u20131.55). No significant association was observed between clinical obesity and new\u2010onset AF in participants with a history of using anti\u2010hypertensive agents (HR: 0.98, 95% CI: 0.73\u20131.30).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Clinical obesity is an independent risk factor for new\u2010onset AF, with age\u2010 and sex\u2010specific associations, while metabolic\u2010targeted therapies were associated with attenuated obesity\u2010associated new\u2010onset AF risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.70893","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T04:09:22Z","timestamp":1779422962000},"page":"6927-6940","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Obesity and New\u2010Onset Atrial Fibrillation: A Population\u2010Based Cohort Study From the Kailuan Cohort"],"prefix":"10.1111","volume":"28","author":[{"given":"Yubing","family":"Guo","sequence":"first","affiliation":[{"name":"Tianjin Key Laboratory of Ionic\u2010Molecular Function of Cardiovascular Disease, Department of Cardiology Tianjin Institute of Cardiology, The Second Hospital of Tianjin Medical University  Tianjin China"},{"name":"Department of Cardiology Luoyang Central Hospital  Luoyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0885-3779","authenticated-orcid":false,"given":"Hongmin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kailuan General Hospital  Tangshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Ionic\u2010Molecular Function of Cardiovascular Disease, Department of Cardiology Tianjin Institute of Cardiology, The Second Hospital of Tianjin Medical University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donglei","family":"Luo","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Ionic\u2010Molecular Function of Cardiovascular Disease, Department of Cardiology Tianjin Institute of Cardiology, The Second Hospital of Tianjin Medical University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Luoyang Central Hospital  Luoyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5510-1253","authenticated-orcid":false,"given":"Gary","family":"Tse","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Ionic\u2010Molecular Function of Cardiovascular Disease, Department of Cardiology Tianjin Institute of Cardiology, The Second Hospital of Tianjin Medical University  Tianjin China"},{"name":"School of Nursing and Health Studies, Hong Kong Metropolitan University  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiotis","family":"Korantzopoulos","sequence":"additional","affiliation":[{"name":"First Department of Cardiology University of Ioannina Medical School  Ioannina Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7566-1626","authenticated-orcid":false,"given":"Gregory Y. 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