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In this narrative review we aim to review real\u2010world, quantitative and qualitative GLP\u20101RA discontinuation, adherence, and persistence evidence as it aligns with an established conceptual framework for understanding medication adherence in noncommunicable chronic disease. Many inconsistencies exist in how discontinuation, adherence, and persistence are studied in this literature. Few qualitative studies have focused on discontinuation of GLP\u20101RAs. Quantitative approaches often focus on medication\u2010related factors and more superficial aspects of socioeconomic and condition\u2010related factors. Very few studies encompass all 5 dimensions of the medication adherence conceptual framework. Patient\u2010related factors, especially related to patient behaviors, are understudied in relation to GLP\u20101RA discontinuation. Patients treated for type 2 diabetes mellitus or weight management with GLP\u20101RAs often discontinue the medication, but this is often nonpermanent. Improving adherence to and persistence on GLP\u20101RAs will require nuanced attention to care trajectories as well as an integrated understanding of GLP\u20101RA tolerability, expectations, and the understudied role of patient behaviors and the healthcare system. To clarify relevant mechanisms and guide targeted intervention for highest\u2010risk individuals, further study should standardize definitions of persistence and discontinuation and implement patient\u2010centered qualitative work, especially related to health behaviors.<\/jats:p>","DOI":"10.1111\/dom.70913","type":"journal-article","created":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T08:06:31Z","timestamp":1780646791000},"page":"6533-6549","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Rates of, Reasons for, and Reactions to Discontinuation of\n                    <scp>GLP<\/scp>\n                    \u20101 Receptor Agonists: A Narrative Review"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8136-2625","authenticated-orcid":false,"given":"Henry D.","family":"Heisey","sequence":"first","affiliation":[{"name":"Center for Innovations in Quality, Effectiveness and Safety Michael E DeBakey VA Medical Center  Houston Texas USA"},{"name":"South Central Mental Illness Research Education and Clinical Center  Houston Texas USA"},{"name":"Menninger Department of Psychiatry and Behavioral Sciences Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. Parker","family":"Gregg","sequence":"additional","affiliation":[{"name":"Center for Innovations in Quality, Effectiveness and Safety Michael E DeBakey VA Medical Center  Houston Texas USA"},{"name":"Selzman Institute for Kidney Health, Section of Nephrology Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher D.","family":"Verrico","sequence":"additional","affiliation":[{"name":"Center for Innovations in Quality, Effectiveness and Safety Michael E DeBakey VA Medical Center  Houston Texas USA"},{"name":"Menninger Department of Psychiatry and Behavioral Sciences Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis T.","family":"Villareal","sequence":"additional","affiliation":[{"name":"Center for Translational Research on Inflammatory Diseases Michael E DeBakey VA Medical Center  Houston Texas USA"},{"name":"Division of Endocrinology, Diabetes, and Metabolism Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terri L.","family":"Fletcher","sequence":"additional","affiliation":[{"name":"Center for Innovations in Quality, Effectiveness and Safety Michael E DeBakey VA Medical Center  Houston Texas USA"},{"name":"South Central Mental Illness Research Education and Clinical Center  Houston Texas USA"},{"name":"Menninger Department of Psychiatry and Behavioral Sciences Baylor College of Medicine  Houston Texas 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