{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:15:40Z","timestamp":1789172140696,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,5,31]],"date-time":"2026-05-31T00:00:00Z","timestamp":1780185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,31]],"date-time":"2026-05-31T00:00:00Z","timestamp":1780185600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To provide updated agent\u2010level comparative estimates of GLP\u20101\u2010based therapies for cardiovascular outcomes in adults with Type 2 diabetes mellitus (T2DM) using a hazard ratio (HR)\u2010based systematic review and network meta\u2010analysis (NMA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PubMed, Cochrane Library and Scopus were searched through December 2025 for randomized controlled trials evaluating GLP\u20101\u2010based therapies in adults with T2DM and reporting time\u2010to\u2010event cardiovascular outcomes. Pairwise meta\u2010analyses and a frequentist random\u2010effects NMA were performed for all\u2010cause mortality, cardiovascular mortality, major adverse cardiovascular events (MACE), non\u2010fatal myocardial infarction (MI) and non\u2010fatal stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fifteen trials involving 97,173 participants were included. In pairwise placebo\u2010controlled analyses, GLP\u20101\u2010based therapies significantly reduced all\u2010cause mortality, cardiovascular mortality and MACE. In the NMA, mortality estimates for several agents favoured benefit, although most comparisons were not statistically significant. For MACE, efpeglenatide, albiglutide and injectable semaglutide showed the most favourable comparative profiles. Albiglutide reduced non\u2010fatal MI versus placebo, whereas non\u2010fatal stroke estimates were imprecise.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>GLP\u20101\u2010based therapies were associated with an overall favourable cardiovascular profile in T2DM. Pairwise analyses supported class\u2010level benefit, whereas between\u2010agent differences were more evident for MACE than for mortality outcomes in the NMA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.70915","type":"journal-article","created":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T01:38:07Z","timestamp":1780277887000},"page":"7137-7148","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Impact of\n                    <scp>GLP<\/scp>\n                    \u20101\u2010Based Therapies on Cardiovascular Outcomes in Type 2 Diabetes: A Comprehensive Systematic Review and Network Meta\u2010Analysis"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8622-1968","authenticated-orcid":false,"given":"Shih\u2010Ming","family":"Chuang","sequence":"first","affiliation":[{"name":"School of Medicine, College of Medicine MacKay Medical University  New Taipei City 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