{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T18:36:08Z","timestamp":1793126168581,"version":"4.5.0"},"reference-count":50,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004191","name":"Novo Nordisk","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004191","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>\n                      This study aimed to indirectly compare the effects of oral semaglutide 25\u2009mg versus orforglipron 36\u2009mg on body weight loss, other cardiometabolic biomarkers, and tolerability in adults with overweight (body mass index [BMI] \u2265\u200927\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      and at least one obesity\u2010related complication) or obesity (BMI \u2265\u200930\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ), without diabetes, using data from OASIS 4 and ATTAIN\u20101.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Individual patient data from OASIS 4 and aggregate data from ATTAIN\u20101 informed anchored indirect treatment comparisons (ITCs). Baseline differences in sex, body weight and normoglycaemic status were adjusted for using population\u2010adjustment methods. Efficacy (percentage body weight change, categorical body weight loss thresholds, other cardiometabolic biomarkers) and tolerability outcomes (treatment discontinuation due to any adverse event [AE] and due to gastrointestinal [GI] AEs) were analysed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Population\u2010adjusted analyses showed a significantly greater percentage change from baseline in body weight with oral semaglutide 25\u2009mg than with orforglipron 36\u2009mg, with mean differences (MDs) of \u22123.2%\u2010points (95% confidence intervals [CIs]: \u22125.9, \u22120.4; treatment\u2010regimen estimand) and \u22123.0%\u2010points (95% CI: \u22125.8, \u22120.3; efficacy estimand). Discontinuation was higher with orforglipron (due to any AE: odds ratio [OR]: 4.1 [95% CI: 1.3, 13.0] and due to GI AEs: OR: 13.9 [95% CI: 2.0, 96.0]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this ITC, oral semaglutide 25\u2009mg was associated with greater body weight loss and fewer discontinuations due to any AEs and due to GI AEs compared with orforglipron 36\u2009mg. These findings provide insight into the comparative effectiveness and tolerability in the absence of head\u2010to\u2010head clinical trials.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.70919","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:38:19Z","timestamp":1780360699000},"page":"7247-7256","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Oral Semaglutide 25\u2009mg Versus Orforglipron 36\u2009mg in Obesity: A Population\u2010Adjusted Indirect Treatment Comparison"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3390-0182","authenticated-orcid":false,"given":"Wojciech","family":"Michalak","sequence":"first","affiliation":[{"name":"Novo Nordisk Inc.  Plainsboro New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"B\u00f8g","sequence":"additional","affiliation":[{"name":"Novo Nordisk A\/S  S\u00f8borg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theiss","family":"Bendixen","sequence":"additional","affiliation":[{"name":"Novo Nordisk A\/S  S\u00f8borg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohan","family":"Chowdhury","sequence":"additional","affiliation":[{"name":"Petauri Evidence  Bicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phoebe","family":"Cowley","sequence":"additional","affiliation":[{"name":"Petauri Evidence  Bicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Laugesen","sequence":"additional","affiliation":[{"name":"Novo Nordisk A\/S  S\u00f8borg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naveen","family":"Rathor","sequence":"additional","affiliation":[{"name":"Novo Nordisk A\/S  S\u00f8borg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert F.","family":"Kushner","sequence":"additional","affiliation":[{"name":"Northwestern University Feinberg School of Medicine  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,1]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"World Health Organization (WHO) \u201cObesity and Overweight\u201d accessed February 5 2026 https:\/\/www.who.int\/news\u2010room\/fact\u2010sheets\/detail\/obesity\u2010and\u2010overweight."},{"key":"e_1_2_11_3_1","volume-title":"The Heavy Burden of Obesity: The Economics of Prevention","author":"Organisation for Economic Co\u2010operation and Development (OECD)","year":"2019"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.13317"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(18)32822\u20108"},{"key":"e_1_2_11_6_1","unstructured":"Centers for Disease Control and Prevention (CDC) \u201cNational Health and Nutrition Examination Survey (NHANES) August 2021\u2010August 2023\u201d(2023) accessed February 5 2026 https:\/\/wwwn.cdc.gov\/nchs\/nhanes\/continuousnhanes\/default.aspx?Cycle=2021\u20102023."},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010024\u201003095\u20103"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14061259"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g2646"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2013.162"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgz140"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12932"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40842\u2010025\u201000245\u20105"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41366\u2010025\u201001859\u20106"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina61010153"},{"key":"e_1_2_11_16_1","unstructured":"U.S. Food and Drug Administration \u201cWegovy (Semaglutide) Injection and Tablets: Prescribing Information\u201daccessed February 23 2026 https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2025\/218316Orig1s000lbl.pdf."},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2500969"},{"key":"e_1_2_11_18_1","unstructured":"U.S. Food and Drug Administration FDA Approves First New Molecular Entity Under National Priority Voucher Programaccessed April 7 2026 https:\/\/www.fda.gov\/news\u2010events\/press\u2010announcements\/fda\u2010approves\u2010first\u2010new\u2010molecular\u2010entity\u2010under\u2010national\u2010priority\u2010voucher\u2010program."},{"key":"e_1_2_11_19_1","unstructured":"Eli Lilly and Company \u201cFoundayo (Orforglipron) US Prescribing Information\u201daccessed April 7 2026 https:\/\/pi.lilly.com\/us\/foundayo\u2010uspi.pdf."},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2511774"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.70783"},{"key":"e_1_2_11_22_1","unstructured":"Health Technology Assessment Coordination Group (HTA CG) \u201cMethodological Guideline for Quantitative Evidence Synthesis: Direct and Indirect Comparisons\u201d(2024)."},{"key":"e_1_2_11_23_1","unstructured":"National Center for Biotechnology Information \u201cResearch Study Looking at How Well Semaglutide Tablets Taken Once Daily Work in People Who Have a Body Weight Above the Healthy Range (OASIS 4)\u201daccessed February 24 2026 https:\/\/clinicaltrials.gov\/study\/NCT05564117."},{"key":"e_1_2_11_24_1","unstructured":"National Center for Biotechnology Information A Study of Orforglipron (LY3502970) in Adult Participants With Obesity or Overweight With Weight\u2010Related Comorbidities (ATTAIN\u20101)accessed February 24 2026 https:\/\/clinicaltrials.gov\/study\/NCT05869903."},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/1753\u20100407.70063"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1210\/jendso\/bvab048.046"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc24\u20101678"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.23732"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2106918"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(21)00213\u20100"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1411892"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.9676"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/jrsm.1565"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12874\u2010022\u201001692\u20109"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1177\/0272989X17725740"},{"key":"e_1_2_11_36_1","unstructured":"D. M.Phillippo A. E.Ades S.Dias S.Palmer K. R.Abrams andN. J.Welton \u201cNICE DSU Technical Support Document 18: Methods for Population\u2010Adjusted Indirect Comparisons in Submissions to NICE\u201daccessed January 4 2026 https:\/\/sheffield.ac.uk\/nice\u2010dsu\/tsds\/full\u2010list."},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.8759"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0895\u20104356(97)00049\u20108"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1177\/0272989X12458724"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/psp4.12091"},{"key":"e_1_2_11_41_1","unstructured":"National Center for Biotechnology Information Research Study to Investigate How Well Semaglutide Tablets Taken Once Daily Work in People Who Are Overweight or Living With Obesity (OASIS 1)accessed February 25 2026 https:\/\/clinicaltrials.gov\/study\/NCT05035095."},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/pst.331"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph17020199"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213\u20108587(19)30084\u20101"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2014.10.039"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(11)60105\u20100"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574\u2010019\u20100310\u20107"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehae508"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(23)01185\u20106"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2025.3599"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.24042"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dom-pubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dom.70919","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/dom.70919","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dom.70919","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T18:17:59Z","timestamp":1793125079000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.onlinelibrary.wiley.com\/doi\/10.1111\/dom.70919"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,1]]},"references-count":50,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1111\/dom.70919"],"URL":"https:\/\/doi.org\/10.1111\/dom.70919","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/DOM.70919\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.70919\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.70919\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.70919\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.70919\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.70919\/v1\/review2","asserted-by":"object"}]},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"value":"1462-8902","type":"print"},{"value":"1463-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,1]]},"assertion":[{"value":"2026-04-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}