{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:18:00Z","timestamp":1789172280695,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,5,31]],"date-time":"2026-05-31T00:00:00Z","timestamp":1780185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,31]],"date-time":"2026-05-31T00:00:00Z","timestamp":1780185600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Despite treatment with renin\u2013angiotensin system inhibitors (RASis) and sodium\u2013glucose cotransporter 2 inhibitors (SGLT2is), diabetic kidney disease (DKD) continues to exhibit substantial residual renal risk. The renoprotective effects of adding finerenone to dual therapy remain incompletely characterised.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 255 patients with DKD receiving combined RASi and SGLT2i therapy were analysed by intention\u2010to\u2010treat as triple combination therapy (TCT) with finerenone or dual combination therapy (DCT) alone. The outcomes were longitudinal changes in proteinuria, serum potassium and estimated glomerular filtration rate (eGFR) slope, including total eGFR slope over 24\u2009months and the post\u2013initial dip eGFR slope from 3 to 24\u2009months, evaluated before and after propensity score (PS) matching.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Over a 24\u2010month follow\u2010up period, TCT was associated with a greater and sustained reduction in proteinuria compared with DCT, with significant reductions of 47% at 24\u2009months (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.028). Although the total eGFR slope did not differ significantly between groups, the post\u2013initial dip slope was significantly improved in the TCT group, with an attenuation of annual eGFR decline by approximately 1.31\u2009mL\/min\/1.73\u2009m\n                      <jats:sup>2<\/jats:sup>\n                      \/year (95% CI: 0.25 to 2.36) compared with DCT (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.015). After PS matching, this association remained significant (between\u2010group difference 1.45\u2009mL\/min\/1.73\u2009m\n                      <jats:sup>2<\/jats:sup>\n                      \/year; 95% CI: 0.32\u20132.58;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.012). Serum potassium increased modestly in the early phase of TCT but stabilised thereafter, with no significant difference between groups at 24\u2009months.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Among patients with DKD receiving RASi and SGLT2i therapy, the addition of finerenone was associated with greater proteinuria reduction and a significant improvement in the post\u2013initial dip eGFR slope, suggesting that TCT may offer an additional renoprotective strategy in DKD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.70934","type":"journal-article","created":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T01:39:16Z","timestamp":1780277956000},"page":"7171-7179","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Adding Finerenone to\n                    <scp>SGLT2<\/scp>\n                    Inhibitors and Long\u2010Term Kidney Outcomes in Diabetic Kidney Disease"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9646-6363","authenticated-orcid":false,"given":"Masaru","family":"Matsui","sequence":"first","affiliation":[{"name":"Department of Nephrology Nara Medical University  Nara Japan"},{"name":"Department of Nephrology Nara Prefectural General Medical Center  Nara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatoshi","family":"Nishimoto","sequence":"additional","affiliation":[{"name":"Department of Nephrology Nara Medical University  Nara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaaki","family":"Kosugi","sequence":"additional","affiliation":[{"name":"Department of Nephrology Nara Medical University  Nara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunsuke","family":"Kitamura","sequence":"additional","affiliation":[{"name":"Department of Nephrology Nara Medical University  Nara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiko","family":"Oda","sequence":"additional","affiliation":[{"name":"Department of Nephrology Nara Prefectural General Medical Center  Nara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Kawakami","sequence":"additional","affiliation":[{"name":"Department of Nephrology Nara Prefectural General Medical Center  Nara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Itano","sequence":"additional","affiliation":[{"name":"Department of Nephrology Nara Prefectural General Medical Center  Nara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Uemura","sequence":"additional","affiliation":[{"name":"Department of Nephrology Nara Medical University  Nara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Tamaki","sequence":"additional","affiliation":[{"name":"Department of Nephrology Nara Medical University  Nara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hikari","family":"Tasaki","sequence":"additional","affiliation":[{"name":"Department of Nephrology Nara Medical University  Nara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisuke","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Department of Nephrology Nara Medical University  Nara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8422-7314","authenticated-orcid":false,"given":"Masahiro","family":"Eriguchi","sequence":"additional","affiliation":[{"name":"Department of Nephrology Nara Medical University  Nara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken\u2010ichi","family":"Samejima","sequence":"additional","affiliation":[{"name":"Department of Nephrology Nara Medical University  Nara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiko","family":"Tsuruya","sequence":"additional","affiliation":[{"name":"Department of Nephrology Nara Medical University  Nara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,31]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa011161"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa011303"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1208799"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1306033"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000550676"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006080860"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1811744"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2024816"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2110956"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2025845"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.15765"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2410659"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.34067\/KID.0000000886"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41440-018-0158-6"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.14601"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000083982.74108.54"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41440-019-0320-9"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2005.00756.x"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.00240106"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5001854"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-024-03263-5"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2022.08.040"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metop.2023.100251"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-64640-3"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfac234"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2021.10.008"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.123.067584"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.0000000000000149"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2407107"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2024.10.091"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.117.10360"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.657957"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2021070942"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.14694"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics17111370"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.121.057736"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dom-pubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dom.70934","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/dom.70934","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dom.70934","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T23:46:32Z","timestamp":1789170392000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.onlinelibrary.wiley.com\/doi\/10.1111\/dom.70934"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,31]]},"references-count":36,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1111\/dom.70934"],"URL":"https:\/\/doi.org\/10.1111\/dom.70934","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/DOM.70934\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.70934\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.70934\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.70934\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.70934\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.70934\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.70934\/v1\/review4","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.70934\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.70934\/v1\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.70934\/v2\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.70934\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.70934\/v2\/review1","asserted-by":"object"}]},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"value":"1462-8902","type":"print"},{"value":"1463-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,31]]},"assertion":[{"value":"2026-03-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}