{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T18:36:13Z","timestamp":1793126173576,"version":"4.5.0"},"reference-count":44,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Urogenital adverse events are common with sodium\u2010glucose co\u2010transporter 2 inhibitors (SGLT2i) and may influence treatment decisions. Variations in SGLT2i selectivity, potency and effects on renal glucose excretion could lead to differences in safety profiles. We compared the risks of urinary tract infection (UTI), genital tract infection (GTI) and phimosis among adults with Type 2 diabetes who initiated empagliflozin versus dapagliflozin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>This population\u2010based, active\u2010comparator, new\u2010user cohort study emulating a target trial included adult metformin users initiating empagliflozin or dapagliflozin during 2015\u20132022. We identified UTIs and GTIs through pharmacy antimicrobial prescriptions and inpatient or outpatient diagnoses. Phimosis was identified through hospital diagnoses and procedure codes. Baseline characteristics were balanced using inverse probability of treatment weighting, and cumulative risks and risk ratios were estimated using an intention\u2010to\u2010treat approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The study population included 53\u2009083 empagliflozin and 33\u2009349 dapagliflozin initiators, with median follow\u2010up ranging from 2.6 to 3.8\u2009years across outcomes. The weighted 1\u2010year UTI risk was similar between groups (empagliflozin 10.3% vs. dapagliflozin 10.6%, RR 0.98 [95% CI, 0.95\u20131.01]). Risks of GTI (2.2% vs. 2.0%, RR 1.14 [95% CI, 1.04\u20131.25]), and phimosis (1.0% vs. 0.8%, RR 1.23 [95% CI, 1.04\u20131.52]) were slightly higher with empagliflozin, though absolute risk differences were small. Safety profiles were consistent throughout 5\u2010year follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Initiation of empagliflozin versus dapagliflozin was associated with comparable absolute risks of urogenital adverse events, and slightly higher relative risks of GTI and phimosis among empagliflozin initiators, supporting broadly similar safety profiles.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.70937","type":"journal-article","created":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T01:53:23Z","timestamp":1780538003000},"page":"7367-7379","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Empagliflozin Versus Dapagliflozin and Urogenital Adverse Events in Type 2 Diabetes: A Target Trial Emulation"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-7226-2488","authenticated-orcid":false,"given":"Christine","family":"Ljungberg","sequence":"first","affiliation":[{"name":"Department of Clinical Epidemiology and Center for Population Medicine University and Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasper","family":"Bonnesen","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Copenhagen University Hospital\u2014Bispebjerg and Frederiksberg  Copenhagen Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"},{"name":"Department of Cardiology G\u00f8dstrup Hospital  Herning Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"},{"name":"Department of Cardiology G\u00f8dstrup Hospital  Herning Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Vandenbroucke\u2010Grauls","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and Center for Population Medicine University and Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Medical Microbiology and Infection Control Amsterdam University Medical Centers  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Dalager\u2010Pedersen","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Aalborg University Hospital  Aalborg Denmark"},{"name":"Department of Clinical Medicine Aalborg University  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik Toft","family":"S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and Center for Population Medicine University and Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mette","family":"N\u00f8rgaard","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and Center for Population Medicine University and Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9135-3474","authenticated-orcid":false,"given":"Reimar Wernich","family":"Thomsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and Center for Population Medicine University and Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2017.07.018"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-006-0570-3"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2014.06.009"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12894-023-01392-6"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2244"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwx049"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13959"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.2337\/dci22-0034"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13531"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgab274"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-018-1116-0"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc24\u20102169"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)02074-8"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/14791641211011016"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.7326\/M18-3136"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc20-1464"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc25-0693"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.021887"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.124.068613"},{"issue":"1","key":"e_1_2_9_21_1","first-page":"S181","article-title":"Pharmacologic Approaches to Glycemic Treatment: Standards of Care in Diabetes\u20142025","volume":"48","author":"Committee ADAPP","year":"2024","journal-title":"Diabetes Care"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyw116"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.34067\/KID.0002772021"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2024.7357"},{"issue":"4","key":"e_1_2_9_25_1","first-page":"593","article-title":"Comparison of Efficacy and Safety Profile of Empagliflozin Versus Dapagliflozin as Add on Therapy in Type 2 Diabetic Patients","volume":"33","author":"Hussain M.","year":"2021","journal-title":"Journal of Ayub Medical College, Abbottabad"},{"issue":"4","key":"e_1_2_9_26_1","article-title":"Comparison of Efficacy and Safety Profile of Sodium\u2010Glucose Cotransporter\u20102 Inhibitors as Add\u2010On Therapy in Patients With Type 2 Diabetes","volume":"13","author":"Hussain M.","year":"2021","journal-title":"Cureus"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40256-024-00648-2"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwv254"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2025-087179"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-014-9930-3"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S91125"},{"issue":"3","key":"e_1_2_9_32_1","first-page":"798","article-title":"Data Resource Profile: The Danish National Prescription Registry","volume":"46","author":"Potteg\u00e5rd A.","year":"2017","journal-title":"International Journal of Epidemiology"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S245060"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2025-084909"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0092891"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2015.05.011"},{"key":"e_1_2_9_37_1","unstructured":"D. M. L.Saunte \u201cGuidelines for Superficielle Svampeinfektioner \u201d2012 https:\/\/dds.nu\/wp\u2010content\/uploads\/2012\/08\/Guidelines\u2010for\u2010superficielle\u2010svampeinfektioner_version\u20102.pdf."},{"key":"e_1_2_9_38_1","first-page":"1","article-title":"An Introduction to Competing Risks in Epidemiology","volume":"18","author":"S\u00f8rensen H.","year":"2026","journal-title":"Clinical Epidemiology"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2019.04.035"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2011.01359.x"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12073"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1677-5538.IBJU.2013.01.08"},{"key":"e_1_2_9_43_1","unstructured":"\u201cUrinvejsinfektioner i Almen Praksis \u201d2020 https:\/\/www.dsam.dk\/vejledninger\/urinvejsinfektioner\/urinvejsinfektioner\u2010i\u2010almen\u2010praksis#urinproever\u2010\u2010og\u2010dyrkninger."},{"key":"e_1_2_9_44_1","unstructured":"\u201cFarmakologisk Behandling of Type 2\u2010Diabetes \u201d2023 https:\/\/www.dsam.dk\/vejledninger\/fb\u2010type2\/farmakologisk\u2010behandling\u2010af\u2010hyperglykaemi#1\u2010valg."},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S469958"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dom-pubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dom.70937","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/dom.70937","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dom.70937","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T18:18:52Z","timestamp":1793125132000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.onlinelibrary.wiley.com\/doi\/10.1111\/dom.70937"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,3]]},"references-count":44,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1111\/dom.70937"],"URL":"https:\/\/doi.org\/10.1111\/dom.70937","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/DOM.70937\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.70937\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.70937\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.70937\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.70937\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.70937\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.70937\/v1\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.70937\/v1\/review4","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.70937\/v1\/review5","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.70937\/v1\/review6","asserted-by":"object"}]},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"value":"1462-8902","type":"print"},{"value":"1463-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,3]]},"assertion":[{"value":"2026-03-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}