{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:15:24Z","timestamp":1789172124116,"version":"build-2803163510"},"reference-count":57,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To quantify the incremental economic and utilization burden of comorbid obstructive sleep apnea (OSA) within an overweight to severely obese adult population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study utilized 2016\u20132025 IQVIA PharMetrics Plus Closed Health Plan commercial claims data to identify overweight to severely obese adults aged 18\u201364\u2009years. Patients with diagnosed OSA were propensity\u2010score matched 1:1 to non\u2010OSA controls. Generalized linear models were constructed to quantify the incremental burden of OSA through adjusted cost\/rate ratios and average marginal effects (AMEs) over a 365\u2010day follow up period. Outcomes were also stratified by obesity severity, cardiovascular disease (CVD), diabetes, sex, and baseline glucagon\u2010like peptide\u20101 receptor agonist (GLP\u20101 RA) use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among OSA patients, 13\u2009971 (99.9%) were successfully matched (total\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200927\u2009942). Patients with OSA incurred significantly higher total healthcare costs compared to controls (adjusted cost ratio\u2009=\u20091.24; 95% CI\u2009=\u2009[1.20, 1.28]), corresponding to an AME of $6942 per patient. Costs were driven by routine disease management such as outpatient visits (AME\u2009=\u2009$2955) and prescription costs (AME\u2009=\u2009$3198). Subgroup analyses revealed that incremental costs were high among patients with CVD (AME\u2009=\u2009$9257) and notably, the incremental cost of OSA remained substantial even among chronic users of GLP\u20101 RAs (AME\u2009=\u2009$12359).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Comorbid OSA is associated with a significant increase in total healthcare costs driven largely by outpatient and prescription costs. This burden was concentrated among patients with cardiovascular comorbidity and persisted among chronic GLP\u20101 RA users.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.70938","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T01:14:50Z","timestamp":1780967690000},"page":"7517-7526","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Investigating the Incremental Cost and Utilization Burden of Obstructive Sleep Apnea in Overweight to Severely Obese Patients"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-3194-4016","authenticated-orcid":false,"given":"Hyung Seok John","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Practice, Sciences, and Health Outcomes Research University of Maryland Baltimore  Baltimore Maryland 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