{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:18:01Z","timestamp":1789172281800,"version":"build-2803163510"},"reference-count":43,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001648","name":"European Foundation for the Study of Diabetes","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001648","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003035","name":"Aase og Ejnar Danielsens Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003035","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>While being recognised for stimulating pancreatic insulin secretion, GIP and GLP\u20101 exert various extrapancreatic effects relevant in the context of incretin\u2010based therapies. Here, we evaluated the extrapancreatic effects of GIP and GLP\u20101, separately and combined, on postprandial physiology in totally pancreatectomised individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      In a randomised double\u2010blind design, 12 totally pancreatectomised individuals (five women, age: [mean\u2009\u00b1\u2009SD] 58.8\u2009\u00b1\u200913.9\u2009years; BMI: 24.7\u2009\u00b1\u20095.1\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ) each underwent four liquid mixed meal tests (480\u2009kcal) during 270\u2010min intravenous infusions of GIP (4\u2009pmol\/kg\/min), GLP\u20101 (1\u2009pmol\/kg\/min), GIP+GLP\u20101 and saline (placebo), respectively. Blood samples, appetite\u2010related measures, hemodynamic measures, and\n                      <jats:italic>ad libitum<\/jats:italic>\n                      food intake data were collected. Participants continued basal insulin but omitted other medications including bolus insulin from 10\u2009p.m. the night before.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared to placebo, GLP\u20101 infusion reduced postprandial glucose excursions by 45%\u2009\u00b1\u200948% (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005) and gastric emptying rate by 29%\u2009\u00b1\u200936%, assessed by acetaminophen absorption (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.05), whereas the effects of GIP were similar to placebo. During GIP+GLP\u20101 co\u2010infusion,\n                      <jats:italic>ad libitum<\/jats:italic>\n                      food intake was 31%\u2009\u00b1\u200922% lower compared to placebo (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.018) but similar to GLP\u20101 infusion. Compared to placebo, infusion of GIP increased heart rate by 10\u2009\u00b1\u20095.9\u2009bpm (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004), decreased diastolic blood pressure by 9.1\u2009\u00b1\u20095.4\u2009bpm (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002), and inhibited postprandial bone resorption assessed by carboxy\u2010terminal collagen crosslinks by 65%\u2009\u00b1\u200935% (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003), whereas GLP\u20101 infusion did not affect bone resorption markers.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Physiological actions of GIP and GLP\u20101 were preserved in totally pancreatectomised individuals, demonstrating independency of endogenous pancreatic factors.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      : NCT06895408\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.70940","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:36:42Z","timestamp":1780360602000},"page":"7280-7290","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Acute\n                    <scp>GIP<\/scp>\n                    and\n                    <scp>GLP<\/scp>\n                    \u20101 Administration Exerts Differential Metabolic Effects in Totally Pancreatectomised Individuals"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-0815-1380","authenticated-orcid":false,"given":"Liva S. L.","family":"Krogh","sequence":"first","affiliation":[{"name":"Center for Clinical Metabolic Research, Gentofte Hospital University of Copenhagen  Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maja B.","family":"Hansen","sequence":"additional","affiliation":[{"name":"Center for Clinical Metabolic Research, Gentofte Hospital University of Copenhagen  Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha C.","family":"Bergmann","sequence":"additional","affiliation":[{"name":"Center for Clinical Metabolic Research, Gentofte Hospital University of Copenhagen  Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten P.","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Surgery and Transplantation, Rigshospitalet Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bolette","family":"Hartmann","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"},{"name":"Novo Nordisk Foundation Center for Basic Metabolic Research University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6853-3805","authenticated-orcid":false,"given":"Jens J.","family":"Holst","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"},{"name":"Novo Nordisk Foundation Center for Basic Metabolic Research University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filip K.","family":"Knop","sequence":"additional","affiliation":[{"name":"Center for Clinical Metabolic Research, Gentofte Hospital University of Copenhagen  Hellerup Denmark"},{"name":"Novo Nordisk A\/S  Bagsv\u00e6rd Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asger B.","family":"Lund","sequence":"additional","affiliation":[{"name":"Center for Clinical Metabolic Research, Gentofte Hospital University of Copenhagen  Hellerup Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"},{"name":"Clinical Research, Steno Diabetes Center Copenhagen University of Copenhagen  Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7880-8515","authenticated-orcid":false,"given":"L\u00e6rke S.","family":"Gasbjerg","sequence":"additional","affiliation":[{"name":"Center for Clinical Metabolic Research, Gentofte Hospital University of Copenhagen  Hellerup Denmark"},{"name":"Department of Biomedical Sciences, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,1]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.03.054"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-023-05956-x"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01316798"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI990"},{"key":"e_1_2_12_6_1","first-page":"1","article-title":"GIP Infusion Acutely Decreases Blood Pressure and Increases Heart Rate in Men With Type 2 Diabetes, Concomitantly With Increased Proatrial Natriuretic Peptide Levels","volume":"65","author":"S\u00f8rum N. 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