{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T17:02:46Z","timestamp":1786122166143,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100004326","name":"Bayer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004326","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This prespecified analysis evaluated whether the safety and efficacy of finerenone and a sodium\u2013glucose cotransporter 2 inhibitor (SGLT2i) combination vary by baseline glycated haemoglobin (HbA1c).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      Adults with type 2 diabetes and a urinary albumin\u2010to\u2010creatinine ratio (UACR) of 100\u2009\u2212\u2009&lt;\u20095000\u2009mg\/g, estimated glomerular filtration rate (eGFR) 30\u201390\u2009mL\/min\/1.73\u2009m\n                      <jats:sup>2<\/jats:sup>\n                      and HbA1c &lt;\u200911% (&lt;\u200997\u2009mmol\/mol) were randomised (1:1:1) to once\u2010daily finerenone, empagliflozin or combination. Primary outcome was UACR change from baseline at Day 180.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Baseline HbA1c was available for 781\/800 CONFIDENCE participants; baseline HbA1c and eGFR mean values (standard deviation) were 7.3% (1.2%) and 54.2\u2009mL\/min\/1.73\u2009m\n                      <jats:sup>2<\/jats:sup>\n                      (17.1\u2009mL\/min\/1.73\u2009m\n                      <jats:sup>2<\/jats:sup>\n                      ). At Day 180, HbA1c decreased with combination therapy and empagliflozin (both least\u2010squares mean change \u22120.1% [95% confidence interval \u22120.2, \u22120.0]), with no change with finerenone. In total, 212, 190, 188 and 191 participants were included in HbA1c Quartiles 1 (HbA1c\u2009\u2264\u20096.4% [\u2264\u200946\u2009mmol\/mol]), 2 (HbA1c\u2009&gt;\u20096.4 and \u2264\u20097.1% [&gt;\u200946 and \u2264\u200954\u2009mmol\/mol]), 3 (HbA1c\u2009&gt;\u20097.1 and \u2264\u20097.9% [&gt;\u200954 and \u2264\u200963\u2009mmol\/mol]) and 4 (HbA1c\u2009&gt;\u20097.9% [&gt;\u200963\u2009mmol\/mol]), respectively. Change from baseline in HbA1c at Day 180 was greatest in Quartile 4. At Day 180, combination therapy reduced UACR from baseline in all HbA1c quartiles to a greater extent than either monotherapy (mean [95% CI] \u201353% [\u221263, \u221242], \u221247% [\u221257, \u221234], \u221263% [\u221270, \u221254] and \u221255% [\u221265, \u221242], in Quartiles 1\u20134, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Simultaneous initiation with finerenone and an SGLT2i reduced UACR compared with monotherapy and was well\u2010tolerated irrespective of HbA1c levels.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.70949","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T02:22:18Z","timestamp":1781576538000},"page":"7964-7973","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Simultaneous Initiation of Finerenone and Empagliflozin on Albuminuria Irrespective of Baseline\n                    <scp>HbA1c<\/scp>\n                    Levels: A Participant\u2010Level Exploratory Analysis of the Randomised\n                    <scp>CONFIDENCE<\/scp>\n                    Trial"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6228-6521","authenticated-orcid":false,"given":"Janet B.","family":"McGill","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Metabolism &amp; Lipid Research Washington University in St. Louis, School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer B.","family":"Green","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Medicine and Duke Clinical Research Institute Duke University School of Medicine  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3126-3730","authenticated-orcid":false,"given":"Hiddo J. 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