{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:14:48Z","timestamp":1789172088977,"version":"build-2803163510"},"reference-count":42,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Glucagon\u2010like peptide\u20101 receptor agonists (GLP\u20101RAs) are used for glycaemic lowering, weight loss and cardio\u2010renal protection. GLP\u20101RAs delay gastric emptying and are implicated in perioperative pulmonary aspiration. Cataract eye surgery is the most common outpatient surgical procedure using mild\u2010to\u2010moderate sedation (MMS). We evaluated whether GLP\u20101RA use is associated with perioperative desaturation and\/or postoperative nausea or vomiting (PONV) during ambulatory ophthalmic surgery using MMS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>A retrospective, observational cohort study of adults who underwent surgery under MMS at the Kensington Eye Institute between January 2022 and December 2024 was conducted. Patients were classified as GLP\u20101RA users or non\u2010users. Primary outcomes were desaturation &lt;\u200990% and PONV requiring antiemetic administration. Associations were assessed using univariate and multivariable logistic regression adjusted for risk factors and potential confounders using a generalized estimating equation (GEE) approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 45\u2009636 visits from 30\u2009328 eligible patients were included, of which 1596 (3.5%) visits from 1036 patients were GLP\u20101RA users. GLP\u20101RA use was not associated with incidence of desaturation [OR(95% CI): 1.22 (0.38\u20133.88),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.74]. GLP\u20101RA use was associated with an increased likelihood of PONV requiring antiemetics [OR(95% CI): 1.93 (1.29\u20132.89),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001]. No perioperative or 24\u2010h postoperative aspiration events were identified in either group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this cohort, no desaturation events occurred, although PONV was more frequent amongst GLP\u20101RA users. These findings support the safety of continued perioperative GLP\u20101RA use in patients meeting strict institutional pre\u2010procedure screening pathways for short\u2010duration ophthalmic surgeries under MMS in an ambulatory setting but may not extend to higher risk patients excluded by institutional criteria. Future guidelines need to incorporate patient\u2010centred symptomatology to guide clinicians in perioperative management of GLP\u20101RA use.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.70955","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T01:11:06Z","timestamp":1780967466000},"page":"7546-7554","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Perioperative Desaturation and Postoperative Nausea or Vomiting Requiring Antiemetic Administration in Glucagon\u2010Like Peptide\u20101 Receptor Agonist Users Undergoing Ambulatory Ophthalmic Surgery Under Mild\u2010To\u2010Moderate Sedation: A Large Retrospective Cohort Study"],"prefix":"10.1111","volume":"28","author":[{"given":"Brian","family":"Hyung","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang Y.","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Princess Margaret Cancer Research Centre, University Health Network  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manokaraananthan","family":"Chandrakumar","sequence":"additional","affiliation":[{"name":"Kensington Eye Institute Kensington Health  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie A.","family":"Lovshin","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Endocrinology and Metabolism University of Toronto, Sunnybrook Research Centre, Sunnybrook Health Sciences Centre, Banting and Best Diabetes Centre  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0023-016X","authenticated-orcid":false,"given":"Sharon Christine","family":"Peacock","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine University of Toronto  Toronto Ontario Canada"},{"name":"Kensington Eye Institute Kensington Health  Toronto Ontario Canada"},{"name":"Department of Anesthesia and Pain Management University Health Network, Sinai Health, and Women's College Hospital  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-023-00849-3"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(21)00203-5"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcjd.2017.10.034"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc23-S002"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.2337\/dci24-0003"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.2337\/db10-0474"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc20-0190"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12630-023-02440-3"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2023.111091"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.14005"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12630-023-02521-3"},{"key":"e_1_2_10_13_1","unstructured":"W.BeamandL.Hunter Guevara \u201cAre Serious Anesthesia Risks of Semaglutide and Other Glp\u20101 Agonists Under\u2010Recognized? 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