{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T05:51:14Z","timestamp":1791697874098,"version":"4.3.4"},"reference-count":106,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:00:00Z","timestamp":1781568000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:00:00Z","timestamp":1781568000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Antidiabetic drugs differ in their effects on body composition, which may influence metabolic and functional outcomes. This systematic review and network meta\u2010analysis aimed to quantify and compare effects of major antidiabetic drugs on key body composition parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PubMed, Web of Science and Scopus were searched from inception to March 2025 for randomized controlled trials. Network meta\u2010analyses used a frequentist random\u2010effects framework to estimate mean differences (MDs) and 95% confidence intervals (CIs) for changes in fat mass (FM) and lean body mass (LBM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Forty\u2010one trials involving 2906 participants were included. For FM among Glucagon\u2010like peptide\u20101 (GLP\u20101) and dual GLP\u20101 and glucose\u2010dependent insulinotropic polypeptide (GIP) receptor agonists, tirzepatide showed the greatest reduction compared with placebo (MD \u221210.70\u2009kg; 95% CI: \u221213.42 to \u22127.99), followed by liraglutide plus exercise. Semaglutide and liraglutide produced moderate reductions. In contrast, insulin glargine and alogliptin were associated with FM gain relative to metformin and exenatide. For LBM, tirzepatide (MD \u22124.40\u2009kg; 95% CI: \u22127.58 to \u22121.22) and liraglutide (MD \u22121.54\u2009kg; 95% CI: \u22122.55 to \u22120.52) were associated with significant reductions. Sodium\u2013glucose cotransporter\u20102 (SGL2) inhibitors caused minor losses, whereas metformin, insulin regimens and dipeptidyl peptidase\u20104 (DPP4) inhibitors showed neutral effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>GLP\u20101 and dual GIP\/GLP\u20101 receptor agonists produced the greatest FM reduction but also decreased lean mass. Exercise mitigated liraglutide\u2010related LBM loss. SGLT2 inhibitors showed modest effects, while metformin, insulin, DPP4 inhibitors and sulfonylureas had minimal impact. Further research on dose, duration and lifestyle influences is warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.70957","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T03:36:47Z","timestamp":1781667407000},"page":"7689-7704","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Comparative Effects of Antidiabetic Drugs on Body Composition: A Systematic Review and Network Meta\u2010Analysis"],"prefix":"10.1111","volume":"28","author":[{"given":"Seyedeh Samira","family":"Rakhsha","sequence":"first","affiliation":[{"name":"Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute Tehran University of Medical Sciences  Tehran Iran"},{"name":"Students' Scientific Research Center (SSRC) Tehran University of Medical Sciences  Tehran 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