{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T18:45:02Z","timestamp":1791571502927,"version":"4.3.4"},"reference-count":42,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100016834","name":"Chongqing Municipal Health Commission","doi-asserted-by":"publisher","award":["2022ZDXM004"],"award-info":[{"award-number":["2022ZDXM004"]}],"id":[{"id":"10.13039\/100016834","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study aimed to assess the effects of low\u2010dose tirzepatide combined with metformin (COM) versus metformin (MET) monotherapy in overweight\/obese women with polycystic ovary syndrome (PCOS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Sixty overweight\/obese women with PCOS were randomised to the MET group (1000\u2009mg twice daily [BID]) or the COM group (MET: 1000\u2009mg BID, tirzepatide: 5\u2009mg once weekly [QW]) for 16\u2009weeks. The primary outcome was the change in body weight. Secondary outcomes included changes in anthropometric measures other than body weight, body composition, reproductive hormone levels, metabolic and endocrine parameters, inflammatory markers and menstrual cycle regularity. All outcomes were assessed at baseline and week 16. After week 16, participants were switched to MET monotherapy. Barrier contraception was required for 8\u2009weeks and pregnancy outcomes were subsequently evaluated between weeks 25 and 48.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After 16\u2009weeks of treatment, compared with the MET group, the COM group resulted in greater reductions in weight (\u22121.7\u2009\u00b1\u20092.5\u2009kg vs. \u221210.4\u2009\u00b1\u20093.5\u2009kg;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), body mass index (BMI) (\u22120.68\u2009\u00b1\u20091.82 vs. \u22124.12\u2009\u00b1\u20091.37\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), visceral adipose tissue (VAT) (\u22124.67\u2009\u00b1\u20099.59 vs. \u221234.13\u2009\u00b1\u200915.33\u2009cm\n                      <jats:sup>2<\/jats:sup>\n                      ;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and reproductive endocrine\u2010metabolic parameters. Menstrual cycle recovery and total pregnancy rate were higher in the COM group than in the MET group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.013 and\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.014, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In overweight\/obese women with PCOS, low\u2010dose tirzepatide combined with MET was associated with greater reductions in body weight and visceral fat, along with improvements in metabolic and reproductive outcomes compared with MET monotherapy.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      ChiCTR2400090908;\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/chictr.org.cn\">chictr.org.cn<\/jats:ext-link>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.70966","type":"journal-article","created":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T01:53:24Z","timestamp":1780538004000},"page":"7380-7392","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Short\u2010Term Combined Treatment With Tirzepatide and Metformin for Overweight\/Obese Chinese Women With Polycystic Ovary Syndrome: A Prospective, Open\u2010Label, Randomised Controlled Trial"],"prefix":"10.1111","volume":"28","author":[{"given":"Zhuoran","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Endocrinology The Second Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The Second Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hu","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine The Second Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenya","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The Second Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The Second Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongfang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The Second Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9007-5281","authenticated-orcid":false,"given":"Lili","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The Second Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1209-4978","authenticated-orcid":false,"given":"Cong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The Second Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,3]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-024-00511-3"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa285"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(98)00011-9"},{"issue":"11","key":"e_1_2_14_5_1","first-page":"CD003053","article-title":"Insulin\u2010Sensitising Drugs (Metformin, Rosiglitazone, Pioglitazone, D\u2010Chiro\u2010Inositol) for Women With Polycystic Ovary Syndrome, Oligo Amenorrhoea and Subfertility","volume":"11","author":"Morley L. 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