{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:17:39Z","timestamp":1789172259690,"version":"build-2803163510"},"reference-count":38,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To assess whether glucagon\u2010like peptide\u20101 receptor agonists (GLP\u20101RAs) are associated with a lower incidence of age\u2010related ocular diseases in non\u2010diabetic older adults with overweight or obesity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective, propensity score\u2013matched cohort study using the TriNetX global research network. Non\u2010diabetic, overweight or obese adults aged \u2265\u200960\u2009years with an ophthalmic disease\u2013na\u00efve baseline were enrolled. Patients receiving liraglutide or semaglutide were matched 1:1 with users of alternative weight\u2010loss medications (bupropion\u2013naltrexone, phentermine\u2013topiramate, setmelanotide or orlistat). Outcomes included up to 5\u2010year risks of incident cataract, age\u2010related macular degeneration (AMD), ocular hypertension, primary open\u2010angle glaucoma (POAG) and dry eye syndrome (DES).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>After matching, 68\u2009536 patients were included (34\u2009268 per group). GLP\u20101RAs use was significantly associated with a lower 5\u2010year risk of cataract (RR: 0.45; 95% CI, 0.40\u20130.50), AMD (RR: 0.33; 95% CI, 0.23\u20130.48), ocular hypertension (RR: 0.56; 95% CI, 0.34\u20130.91), POAG (RR: 0.50; 95% CI, 0.32\u20130.78) and DES (RR: 0.36; 95% CI, 0.31\u20130.42). Sensitivity analyses consistently demonstrated a lower risk across cataract subtypes, including nuclear (RR: 0.42; 95% CI, 0.37\u20130.48), cortical (RR: 0.37; 95% CI, 0.36\u20130.55) and posterior subcapsular cataracts (RR: 0.48; 95% CI, 0.26\u20130.91). Similar reductions were observed in retinal haemorrhage or edema (RR: 0.44; 95% CI, 0.30\u20130.63) and the use of dry eye\u2010related medication (RR: 0.44; 95% CI, 0.39\u20130.50).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>GLP\u20101RAs were associated with lower risks of multiple age\u2010related ocular conditions in non\u2010diabetic older adults.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.70975","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T01:19:49Z","timestamp":1780967989000},"page":"7580-7591","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Risk of Age\u2010Related Ocular Diseases in Non\u2010Diabetic Adults With Obesity Using Glucagon\u2010Like Peptide 1 Receptor Agonists"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-5557-4558","authenticated-orcid":false,"given":"Kuo\u2010En","family":"Chen","sequence":"first","affiliation":[{"name":"School of Medicine, College of Medicine, Taipei Medical University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po\u2010Chun","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Medicine, College of Medicine, Taipei Medical University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui\u2010An","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Taipei Medical University Hospital  Taipei Taiwan"},{"name":"Department of Emergency Medicine School of Medicine, College of Medicine, Taipei Medical University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0470-2184","authenticated-orcid":false,"given":"Sheng\u2010Feng","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Taipei Medical University Hospital  Taipei Taiwan"},{"name":"Department of Public Health School of Medicine, College of Medicine, Taipei Medical University  Taipei Taiwan"},{"name":"School of Public Health, College of Public Health, Taipei Medical University  Taipei Taiwan"},{"name":"Center of Evidence\u2010Based Medicine Taipei Medical University Hospital  Taipei Taiwan"},{"name":"Department of Medical Research Taipei Medical University Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,8]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo\u20102023\u2010324086"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo\u20102025\u2010327776"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.26074"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2014.05.013"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2022.4394"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26052174"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2016.01.016"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2021.10.006"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.15\u201018637"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/ijg.0000000000000374"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10174021"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1411892"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2032183"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11154\u2010014\u20109289\u20105"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/1479164112441526"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2022.970925"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.2025\u20100531"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2023.07.002"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2025.01.016"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2024.08.023"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2024.2296"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2024.6555"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2025.02.025"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2025.110630"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2025.10.021"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2025.1455"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000004616"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.66.5.15"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26083704"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2024.12.024"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2024.03.004"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol\u20102021\u2010319232"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2025.02.011"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2022.175269"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.2174\/011570159x446766260311123827"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare11202749"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2024.12.003"},{"key":"e_1_2_11_39_1","first-page":"9","article-title":"A Narrative Review of TriNetX in Ophthalmology: Applications, Advantages, and Pitfalls. Annals of","volume":"9","author":"Hackl C. M.","year":"2024","journal-title":"Eye Science"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dom-pubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dom.70975","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/dom.70975","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dom.70975","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T23:44:00Z","timestamp":1789170240000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.onlinelibrary.wiley.com\/doi\/10.1111\/dom.70975"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,8]]},"references-count":38,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1111\/dom.70975"],"URL":"https:\/\/doi.org\/10.1111\/dom.70975","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/DOM.70975\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.70975\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.70975\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.70975\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.70975\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.70975\/v2\/review1","asserted-by":"object"}]},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"value":"1462-8902","type":"print"},{"value":"1463-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,8]]},"assertion":[{"value":"2026-04-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}