{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T17:02:45Z","timestamp":1786122165713,"version":"build-2736575974"},"reference-count":60,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Endoscopic sleeve gastroplasty (ESG), a natural orifice transluminal endoscopic procedure, is increasingly integrated into multidisciplinary obesity care. We performed a systematic review and meta\u2010analysis to quantify the durability of ESG\u2010associated weight loss and metabolic outcomes across short\u2010 and long\u2010term follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Databases were searched from inception to September 2, 2025 (PROSPERO: CRD420251139333). Peer\u2010reviewed studies reporting ESG outcomes were included; primary outcomes were % total body weight loss (%TBWL), % excess body weight loss (%EBWL), and BMI reduction, stratified by follow\u2010up (\u2264\u20096\u2009months vs. \u2265\u20091\u2009year). Random\u2010effects models were used; heterogeneity (\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      ), publication bias (Egger's test), GRADE assessment, sensitivity analyses, and meta\u2010regression for baseline BMI were performed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirty\u2010three studies (8880 patients; 31 cohorts, 2 RCTs) were included. %TBWL increased from 8.66% (1\u2009month) to 16.13% (6\u2009months) and was 17.88% at 1\u2009year. Long\u2010term pooled %TBWL declined modestly over time (17.88% at 1\u2009year to 15.67% at 3\u2009years). Remission rates were 62% for type 2 diabetes, 43% for hypertension, and 43% for dyslipidaemia. Weight regain occurred in 6%. Baseline BMI predicted higher %TBWL but lower %EBWL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>ESG is associated with clinically meaningful weight loss maintained beyond 6\u2009months with modest attenuation over longer follow\u2010up, alongside favourable metabolic remission rates and low reported weight regain.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.70988","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T02:45:13Z","timestamp":1781837113000},"page":"8189-8207","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Short\u2010Term Versus Long\u2010Term Efficacy of Endoscopic Sleeve Gastroplasty in 8880 Obese Patients: A Systematic Review and 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