{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T17:03:54Z","timestamp":1786122234498,"version":"build-2736575974"},"reference-count":40,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82425052"],"award-info":[{"award-number":["82425052"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The relationship between intrinsic capacity (IC), genetic susceptibility, and CVD outcomes in individuals with diabetes remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data were obtained from 18\u2009333 participants with diabetes (58.63\u2009\u00b1\u20097.54\u2009years). The IC deficit score was categorised into five levels: 0, 1, 2, 3, and 4+. Outcomes included: hypertension, IHD, stroke, PAD, HF, and AF. Genetic risk scores (PRS) were constructed based on previously identified single nucleotide polymorphisms (SNPs) associated with these outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Over a follow\u2010up period of 9.91 to 13.43\u2009years. Compared to those with an IC deficit score of 0, diabetes participants with a score of 4+ had significantly elevated risks, particularly for PAD (HR: 3.25, 95% CI: 2.44\u20134.33). The association between IC deficit score and IHD risk was stronger in individuals with low genetic risk. Notably, even among those with high genetic risk, an IC deficit score of 0 was linked to a lower risk of CVD outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In individuals with diabetes, a higher IC deficit score is associated with an increased risk of hypertension, ischemic heart disease, stroke, PAD, HF, and AF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.70990","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T04:00:35Z","timestamp":1781150435000},"page":"7892-7904","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Intrinsic Capacity, Genetic Susceptibility and Incident Cardiovascular Disease Among Individuals With Diabetes: A Prospective Cohort Study"],"prefix":"10.1111","volume":"28","author":[{"given":"Huan","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Epidemiology, School of Public Health Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Fang","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Lin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1597-2676","authenticated-orcid":false,"given":"Zhi\u2010Hao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6537-6215","authenticated-orcid":false,"given":"Chen","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,10]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2019.107843"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc17-1962"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i5953"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60484-9"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc18-0831"},{"key":"e_1_2_14_7_1","volume-title":"Integrated Care for Older People (ICOPE): Guidance for Person\u2010Centred Assessment and Pathways in Primary Care","year":"2019"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00516-4"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.13283"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/circ.150.suppl_1.4137594"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.120.032619"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz849"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/nqac183"},{"issue":"8","key":"e_1_2_14_14_1","first-page":"e93","article-title":"Polygenic Risk Scores for Cardiovascular Disease: A Scientific Statement From the American Heart Association","volume":"146","author":"O'Sullivan J. 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