{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T17:03:52Z","timestamp":1786122232982,"version":"build-2736575974"},"reference-count":19,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Administration of drugs via the oromucosal route, especially using oral thin films, improves patient adherence compared to conventional oral and injectable methods. However, existing production techniques for oral thin films face considerable challenges in incorporating peptide and protein drugs. This study presents electrospun nanofiber\u2010based oral thin film as a viable platform for the sublingual delivery of semaglutide. This platform was tested in G\u00f6ttingen minipigs, which showed a greater response to attenuation of weight gain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Semaglutide\u2010loaded InStrips were produced using electrospinning technology. Forty female, non\u2010diabetic, non\u2010obese G\u00f6ttingen minipigs (6\u20137\u2009months) were divided into groups based on sublingual (\n                      <jats:italic>InStrip<\/jats:italic>\n                      ), peroral (Rybelsus), or subcutaneous (Ozempic) administration of semaglutide over 8\u2009weeks, followed by a 1\u2010week follow\u2010up. InStrip formulations incorporated either sodium dodecyl sulphate (SDS) or sodium\n                      <jats:italic>N<\/jats:italic>\n                      \u2010[8\u2010(2\u2010hydroxybenzoyl)amino] caprylate (SNAC) as permeation enhancers. Sublingual and peroral dosing occurred thrice weekly, whereas subcutaneous administration occurred once weekly.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared to the placebo group, in over 9\u2009weeks, InStrip administration resulted in attenuation in weight gain by 24.9%, surpassing that of the oral tablet (Rybelsus) group. Growth trajectory analysis showed statistically significant differences between the sublingual (InStrip) and placebo group (\n                      <jats:italic>p\u2009=<\/jats:italic>\n                      \u20090.013). In addition to superior weight management, InStrip semaglutide enhanced insulin and C\u2010peptide levels.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Sublingual delivery of semaglutide via InStrip enabled significant weight\u2010modulating effects and improved biomarker responses compared to the placebo group. Despite limitations of a small study group and short duration, this study provides a strong foundation for further evaluation of InStrip as a viable delivery platform for semaglutide administration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.71015","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T02:41:53Z","timestamp":1781577713000},"page":"8034-8044","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Electrospun Nanofiber Oral Thin Film Platform for Sublingual Peptide Delivery: A Promising Alternative to Conventional Semaglutide Formulations"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2936-8461","authenticated-orcid":false,"given":"Gyan","family":"Sagar","sequence":"first","affiliation":[{"name":"InStar Technologies a.s.  Liberec Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronika","family":"Str\u00e1nsk\u00e1","sequence":"additional","affiliation":[{"name":"Prague British International School  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denisa","family":"Str\u00e1nsk\u00e1","sequence":"additional","affiliation":[{"name":"InStar Technologies a.s.  Liberec Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9e","family":"Daams","sequence":"additional","affiliation":[{"name":"Scantox Sweden  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ida","family":"Taavoniku","sequence":"additional","affiliation":[{"name":"Scantox Sweden  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel Y.","family":"Cheong","sequence":"additional","affiliation":[{"name":"Scantox Sweden  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lone Bruhn","family":"Madsen","sequence":"additional","affiliation":[{"name":"Scantox A\/S  Ejby Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,15]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"\u201cReal\u2010life practice: adherence and discontinuation of Rybelsus therapy \u201dhttps:\/\/website\u2010pace.net\/real\u2010life\u2010practice\u2010adherence\u2010and\u2010discontinuation\u2010of\u2010rybelsus\u2010therapy\/."},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00592\u2010024\u201002424\u20109"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2012.11.002"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2023.114904"},{"key":"e_1_2_11_6_1","first-page":"337","article-title":"Validace v\u00fdroby jednod\u00e1vkov\u00fdch medikovan\u00fdch nanovl\u00e1kenn\u00fdch p\u0159\u00edpravk\u016f produkovan\u00fdch elektrospiningem","volume":"113","author":"Str\u00e1nsk\u00e1 D.","year":"2019","journal-title":"Chemicke Listy"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2014.07.017"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2013.08.085"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600820412"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemphyslip.2018.11.005"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11154\u2010022\u201009735\u20108"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.5958\/0974\u2010360X.2021.00247.X"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5b00726"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000036730"},{"key":"e_1_2_11_15_1","unstructured":"FDA \u201cCenter for Drug Evaluation and Research Application Number: 215256Orig1s000 Non\u2010Clinical Review(s)\u201d."},{"key":"e_1_2_11_16_1","unstructured":"A.Zeltner \u201cTaking Good Care of G\u00f6ttingen Minipigs\u201d."},{"key":"e_1_2_11_17_1","volume-title":"Specialist Information from the Committee for Nutrition of Laboratory Animals Feeding Concepts and Methods in Laboratory Animal Husbandry and Animal Experiments\u2010MINIPIG","author":"Simon C.","year":"2019"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125\u2010017\u20104289\u20100"},{"key":"e_1_2_11_19_1","article-title":"Biochemistry, C Peptide","author":"Venugopal S. 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