{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T17:04:40Z","timestamp":1786122280767,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Glucagon\u2010like peptide\u20101 receptor agonists (GLP\u20101 RAs) and the dual GIP\/GLP\u20101 receptor agonist tirzepatide are increasingly used for weight and cardiometabolic management, but real\u2010world prescribing patterns in women with polycystic ovary syndrome (PCOS) remain poorly characterised.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a retrospective cohort study of 38\u2009263 adult women with ICD\u2010coded PCOS in the LUX MED network, Poland, using electronic health records data from July 2006 to April 2026. The primary analysis included women diagnosed with PCOS in 2018\u20132024 and evaluated prescription\u2010recorded initiation of GLP\u20101 RA\/GIP\u2013GLP\u20101 RA therapy within 365\u2009days after the index diagnosis. Temporal trends were assessed using logistic regression with unadjusted and multivariable\u2010adjusted models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, 4557 women (11.9%) had a recorded GLP\u20101 RA\/GIP\u2013GLP\u20101 RA prescription and 16\u2009381 (42.8%) received metformin. Among incretin\u2010based therapy users, 75.5% had metformin co\u2010exposure, whereas only 11.5% had coded type 2 diabetes mellitus. Recorded BMI was higher among GLP\u20101 RA\/GIP\u2013GLP\u20101 RA users than among metformin\u2010only or untreated women (median 31.2 vs. 26.3 and 22.1\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ) and greater comorbidity burden (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Initiation within 365\u2009days rose from 0.14% in 2018 to 5.97% in 2024. Calendar year was strongly associated with initiation (unadjusted OR 1.52, 95% CI, 1.44\u20131.59; adjusted OR 1.64, 95% CI, 1.56\u20131.73; both\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), with consistent results after excluding women with diabetes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Incretin\u2010based therapy use in PCOS increased markedly over time, suggesting expansion beyond classical glycaemic indications toward weight\u2010focused and cardiometabolic management. Studies using dispensing, persistence, safety and outcome data are needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.71017","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T02:43:57Z","timestamp":1781577837000},"page":"8045-8056","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Temporal Trends and Clinical Characteristics of Incretin\u2010Based Therapy Use in Women With Polycystic Ovary Syndrome: A Real\u2010World Cohort Study From a Polish Private Healthcare Network"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2100-5076","authenticated-orcid":false,"given":"Artur","family":"Dziewierz","sequence":"first","affiliation":[{"name":"Clinical Department of Cardiology and Cardiovascular Interventions University Hospital  Krakow Poland"},{"name":"Second Department of Cardiology, Institute of Cardiology Jagiellonian University Medical College  Krakow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Kulicka","sequence":"additional","affiliation":[{"name":"Clinical Department of Cardiology and Cardiovascular Interventions University Hospital  Krakow Poland"},{"name":"Doctoral School of Medical and Health Sciences Jagiellonian University Medical College  Krakow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8849-1141","authenticated-orcid":false,"given":"Kaja","family":"Stolarska","sequence":"additional","affiliation":[{"name":"Collegium Medicum, Jan Kochanowski University  Kielce Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2350-2466","authenticated-orcid":false,"given":"Anesa","family":"Ahmatovic","sequence":"additional","affiliation":[{"name":"Collegium Medicum, Jan Kochanowski University  Kielce Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justyna","family":"Domienik\u2010Kar\u0142owicz","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Cardiology Medical University of Warsaw  Warsaw Poland"},{"name":"Higher School of Medical Sciences, LUX MED Group  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Rulkiewicz","sequence":"additional","affiliation":[{"name":"LUX MED Group  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8033-3977","authenticated-orcid":false,"given":"Zbigniew","family":"Siudak","sequence":"additional","affiliation":[{"name":"Collegium Medicum, Jan Kochanowski University  Kielce Poland"},{"name":"Higher School of Medical Sciences, LUX MED Group  Warsaw Poland"},{"name":"LUX MED Group  Warsaw 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