{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T17:27:04Z","timestamp":1789752424893,"version":"4.0.1"},"reference-count":31,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction and Objective<\/jats:title>\n                    <jats:p>Treatment with sodium\u2010glucose cotransporter\u20102 inhibitors (SGLT\u20102i) reduces the risk of both cardiovascular and renal outcomes in type 2 diabetes (T2D). The specific mechanism by which this happens has not yet been clarified. Recent findings indicate that, in obese individuals, the kidney exhibits lower 18\u2010fluorodeoxyglucose ([18F]\u2010FDG) uptake rates compared to lean individuals, possibly due to insulin resistance. This post hoc analysis from our pilot study DAPAHeart aims to evaluate changes in cortical renal [18F]\u2010FDG uptake in T2D patients following short\u2010term treatment with dapagliflozin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In our DAPAHeart trial, a single\u2010centre, 4\u2010week, prospective, double\u2010blind, controlled study, we enrolled T2D patients with stable coronary artery disease and preserved glomerular filtration rates. Participants were randomly assigned in a 1:1 ratio to receive either dapagliflozin (10\u2009mg daily) or a placebo. PET scans using [18F]\u2010FDG were performed during a hyperinsulinemic\u2010euglycemic clamp (HEC) to measure regional FDG uptake before and after the 4\u2010week treatment with SGLT\u20102i.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After 4\u2009weeks of treatment, the between\u2010group comparison (Mann\u2013Whitney\n                      <jats:italic>U<\/jats:italic>\n                      test on change\u2010from\u2010baseline values) did not reach statistical significance for any SUV parameter. Nevertheless, a consistent directional pattern in renal standardised uptake value (SUV) was noted across all parameters, with reductions observed in the dapagliflozin group and stable or slightly increased values in the placebo group. The within\u2010group analysis revealed a significant reduction in SUV_peak in the dapagliflozin group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.028), while no significant change was detected in the placebo group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Although the primary between\u2010group comparison did not reach statistical significance, likely due to the limited sample size (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20097 per group), a consistent directional pattern was observed across all renal SUV parameters, with reductions in the dapagliflozin group and stable or slightly increased values in the placebo group. These findings suggest decreased glucose uptake in an insulin\u2010stimulated state (HEC) in the dapagliflozin group. Although the causes of this reduction require further investigation, these preliminary findings support the hypothesis that SGLT\u20102 inhibition may reduce tubular energy requirements and glucose uptake, potentially contributing to the preservation of kidney function.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.71026","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T01:37:43Z","timestamp":1782265063000},"page":"8329-8336","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A Four\u2010Week Treatment With Dapagliflozin Is Associated With a Reduction in Insulin\u2010Stimulated Renal Cortical Glucose Uptake: A Post Hoc Analysis From a Pilot Study"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9656-4171","authenticated-orcid":false,"given":"Shawn","family":"Gugliandolo","sequence":"first","affiliation":[{"name":"Centro Malattie Endocrine e Metaboliche, Dipartimento di Scienze Mediche e Chirurgiche Fondazione Policlinico Universitario A. Gemelli IRCCS and Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cassandra","family":"Morciano","sequence":"additional","affiliation":[{"name":"Centro Malattie Endocrine e Metaboliche, Dipartimento di Scienze Mediche e Chirurgiche Fondazione Policlinico Universitario A. Gemelli IRCCS and Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Guarneri","sequence":"additional","affiliation":[{"name":"Unit\u00e0 di Medicina Nucleare Fondazione Policlinico Universitario A. Gemelli IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9489-1534","authenticated-orcid":false,"given":"Gian Pio","family":"Sorice","sequence":"additional","affiliation":[{"name":"Centro Malattie Endocrine e Metaboliche, Dipartimento di Scienze Mediche e Chirurgiche Fondazione Policlinico Universitario A. Gemelli IRCCS and Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"},{"name":"Sezione di Medicina Interna, Endocrinologia, Andrologia e Malattie Metaboliche, Dipartimento di Medicina di Precisione e Rigenerativa e Area Jonica (DiMePRe\u2010J) Universit\u00e0 Degli Studi di Bari \u201cAldo Moro\u201d  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Giaccari","sequence":"additional","affiliation":[{"name":"UOC Nephrology and Dialysis, ASL Roma 1, and Division of Nephrology and Dialysis Bambino Ges\u00f9 Children\u2019s Hospital, IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Cappannoli","sequence":"additional","affiliation":[{"name":"UOC di Cardiologia, Dipartimento di Scienze Cardiovascolari Fondazione Policlinico Universitario A. Gemelli IRCCS and Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umberto","family":"Capece","sequence":"additional","affiliation":[{"name":"Centro Malattie Endocrine e Metaboliche, Dipartimento di Scienze Mediche e Chirurgiche Fondazione Policlinico Universitario A. Gemelli IRCCS and Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amelia","family":"Splendore","sequence":"additional","affiliation":[{"name":"Centro Malattie Endocrine e Metaboliche, Dipartimento di Scienze Mediche e Chirurgiche Fondazione Policlinico Universitario A. Gemelli IRCCS and Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Avolio","sequence":"additional","affiliation":[{"name":"Centro Malattie Endocrine e Metaboliche, Dipartimento di Scienze Mediche e Chirurgiche Fondazione Policlinico Universitario A. Gemelli IRCCS and Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo Diego","family":"Greco","sequence":"additional","affiliation":[{"name":"Centro Malattie Endocrine e Metaboliche, Dipartimento di Scienze Mediche e Chirurgiche Fondazione Policlinico Universitario A. 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Gemelli IRCCS and Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Lucia","family":"Calcagni","sequence":"additional","affiliation":[{"name":"Unit\u00e0 di Medicina Nucleare Fondazione Policlinico Universitario A. Gemelli IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Burzotta","sequence":"additional","affiliation":[{"name":"UOC di Cardiologia, Dipartimento di Scienze Cardiovascolari Fondazione Policlinico Universitario A. Gemelli IRCCS and Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"D'Amario","sequence":"additional","affiliation":[{"name":"UOC di Cardiologia, Dipartimento di Scienze Cardiovascolari Fondazione Policlinico Universitario A. 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