{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T17:03:53Z","timestamp":1786122233304,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T00:00:00Z","timestamp":1782000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T00:00:00Z","timestamp":1782000000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["RS\u20102024\u201000439029"],"award-info":[{"award-number":["RS\u20102024\u201000439029"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS\u20102023\u201000217317"],"award-info":[{"award-number":["RS\u20102023\u201000217317"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Sodium\u2010glucose cotransporter\u20102 inhibitors (SGLT2i) are known to reduce serum urate levels, yet their specific impact on gout incidence in the Korean population remains underexplored. We investigated the association between SGLT2i use and incident gout using real\u2010world data and Mendelian randomisation (MR) analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>We conducted a population\u2010based cohort study using the Korean National Health Insurance Service database (2015\u20132020). New users of SGLT2i were compared to dipeptidyl peptidase\u20104 inhibitor (DPP4i) users. After 1:1 propensity score matching (PSM), 20\u2009866 pairs were analysed using Cox proportional hazards models. The primary outcome was incident gout. Additionally, a two\u2010sample MR analysis utilised genetic variants in SLC5A2 as proxies for SGLT2 inhibition and gout summary statistics from the FinnGen consortium.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In the cohort study, SGLT2i use was associated with a significantly lower risk of gout compared to DPP4i (incidence rate: 2792.6 vs. 3346.7 per 100\u2009000 person\u2010years). The hazard ratio in the PSM model was 0.80 (95% confidence interval [CI] 0.76\u20130.84,\n                      <jats:italic>p<\/jats:italic>\n                      value\u2009&lt;\u20090.001). This finding was robust across multiple sensitivity analyses, including landmark and time\u2010varying exposure models. In the MR analysis, genetically proxied SGLT2 inhibition was associated with a reduced risk of gout (odds ratio 0.10 per 1\u2010standard deviation decrease in HbA1c; 95% CI: 0.017\u20130.463;\n                      <jats:italic>p<\/jats:italic>\n                      value &lt;\u20090.001), with consistent results across robust MR methods.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>SGLT2i therapy is associated with a lower risk of incident gout compared to DPP4i in patients with type 2 diabetes. While these findings suggest potential pleiotropic effects of SGLT2i beyond glucose control, they should be interpreted with caution given the limitations of observational study designs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.71027","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T02:00:41Z","timestamp":1782093641000},"page":"8230-8241","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of Sodium\u2010Glucose Cotransporter\u20102 Inhibitors With Incident Gout Risk: A Population\u2010Based Comparative Cohort Study With Genetic Evidence From Mendelian Randomisation"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8191-4071","authenticated-orcid":false,"given":"Hong Sang","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Chonnam National University Medical School  Gwangju 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Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1727-2822","authenticated-orcid":false,"given":"Eun Hui","family":"Bae","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Chonnam National University Medical School  Gwangju Republic of Korea"},{"name":"Department of Internal Medicine Chonnam National University Hospital  Gwangju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4487-7707","authenticated-orcid":false,"given":"Juhee","family":"Ahn","sequence":"additional","affiliation":[{"name":"Institute of Health and Environment, Seoul National University  Seoul Republic of Korea"},{"name":"Division of Data Science College of Intelligent Software Convergence, University of Suwon  Hwaseong\u2010si Gyeonggi\u2010do Republic of 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