{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T17:03:56Z","timestamp":1786122236927,"version":"build-2736575974"},"reference-count":39,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100020647","name":"Diabetes Victoria","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020647","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001778","name":"Deakin University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001778","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017243","name":"Michigan Diabetes Research Center, University of Michigan","doi-asserted-by":"publisher","award":["P30DK020572"],"award-info":[{"award-number":["P30DK020572"]}],"id":[{"id":"10.13039\/100017243","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["K23DK129724"],"award-info":[{"award-number":["K23DK129724"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01DK142830"],"award-info":[{"award-number":["R01DK142830"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UM1TR004404"],"award-info":[{"award-number":["UM1TR004404"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Use of contemporary diabetes technologies, including continuous glucose monitoring (CGM) and hybrid closed\u2010loop insulin pumps (HCLs), has expanded rapidly among people with Type 1 diabetes. However, limited research has characterised the impact of hypoglycaemia on quality of life in this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analysed cross\u2010sectional survey data from US adults aged \u2265\u200918\u2009years who were using CGM or HCL and who were recruited through the T1D Exchange. Survey responses included participant characteristics, diabetes technology use, and hypoglycaemia\u2010specific quality of life measured by the 12\u2010item Hypoglycaemia Impact Profile (HIP\u201012), which assesses hypoglycaemia\u2010related impact across 12 major life domains. HIP\u201012 composite and domain\u2010specific scores were summarised and compared between CGM\u2010only (without HCL) and HCL users.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The analytic sample included 796 participants (mean age 47\u2009years; 53% female), of whom 23% used CGM only and 77% used HCL. Overall, 96% reported at least one life domain negatively affected by hypoglycaemia, and 31% reported negative impacts across 10 or more of the 12 assessed domains. The most frequently negatively affected domains were\n                      <jats:italic>sleep<\/jats:italic>\n                      ,\n                      <jats:italic>leisure activities<\/jats:italic>\n                      ,\n                      <jats:italic>emotional well\u2010being<\/jats:italic>\n                      ,\n                      <jats:italic>spontaneity<\/jats:italic>\n                      and\n                      <jats:italic>physical activity\/fitness<\/jats:italic>\n                      . Compared with CGM\u2010only users, HCL users reported greater hypoglycaemia\u2010related negative impacts on\n                      <jats:italic>leisure activities<\/jats:italic>\n                      (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001),\n                      <jats:italic>physical activity\/fitness<\/jats:italic>\n                      (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001),\n                      <jats:italic>spontaneity<\/jats:italic>\n                      (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.011),\n                      <jats:italic>sex life<\/jats:italic>\n                      (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.014) and\n                      <jats:italic>work or studies<\/jats:italic>\n                      (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.021).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Hypoglycaemia continues to adversely affect multiple related quality\u2010of\u2010life domains despite using contemporary diabetes technologies. Routine clinical assessment of and clinical support for hypoglycaemia's impact remain important. Further research is needed to clarify the mechanisms underlying these impacts and to guide targeted interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.71028","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T15:17:12Z","timestamp":1782400632000},"page":"8390-8397","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Impact of Hypoglycaemia on Quality of Life in Adults With Type 1 Diabetes Using Contemporary Diabetes Technologies: A US National Survey"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1988-7046","authenticated-orcid":false,"given":"Yu Kuei","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Internal Medicine University of Michigan Medical School  Ann Arbor Michigan 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