{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T17:04:50Z","timestamp":1786122290579,"version":"build-2736575974"},"reference-count":57,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T00:00:00Z","timestamp":1782604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T00:00:00Z","timestamp":1782604800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To evaluate the real\u2010world effectiveness, safety and patient\u2010reported outcomes of biosynthetic semaglutide in adults with type 2 diabetes mellitus (T2DM) receiving routine outpatient care in a cost\u2010constrained setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This 30\u2010week, prospective, multicentre, non\u2010interventional study enrolled adults with T2DM initiating biosynthetic semaglutide. The primary endpoint was change in glycated haemoglobin (HbA1c) from baseline to end of study (EOS). Secondary endpoints included changes in body weight, waist circumference, patient\u2010reported outcomes (DTSQs and SF\u201036v2) and safety.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 217 patients, mean HbA1c decreased from 9.27% to 7.41% at EOS (\u22121.86%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). At EOS, 76.6% achieved HbA1c\u2009&lt;\u20098.0% and 38.7% achieved &lt;\u20097.0%. Mean body weight decreased by \u22127.84\u2009kg (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), with 76.5% achieving \u2265\u20095% weight loss. Significant reductions were also observed in body mass index and waist circumference. Treatment satisfaction and physical quality of life improved significantly. Adverse events were predominantly non\u2010serious and gastrointestinal. No severe hypoglycaemic episodes occurred.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In routine clinical practice, biosynthetic semaglutide was associated with clinically meaningful improvements in glycaemic control, body weight and physical quality of life. The safety profile remained consistent with established semaglutide therapy.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      Australian New Zealand Clinical Trials Registry (ANZCTR): ACTRN12625000610437\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.71043","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:10:21Z","timestamp":1782691821000},"page":"8438-8451","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Real\u2010World Evidence of the Effectiveness and Safety of Biosynthetic Semaglutide in Type 2 Diabetes: A Multicentre Study From Pakistan"],"prefix":"10.1111","volume":"28","author":[{"given":"Arshad","family":"Hussain","sequence":"first","affiliation":[{"name":"North\u2010West General Hospital  Peshawar Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Umar","family":"Wahab","sequence":"additional","affiliation":[{"name":"Umar Diabetes and Foot Care Centre and Umar Diabetes Foundation  Islamabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saleem","family":"Qureshi","sequence":"additional","affiliation":[{"name":"Department of Medicine Center for Diabetes and Liver Disease  Islamabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umar Yousaf","family":"Raja","sequence":"additional","affiliation":[{"name":"Shifa International Hospitals Ltd.  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