{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T04:38:54Z","timestamp":1792471134154,"version":"4.5.0"},"reference-count":45,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To assess the effects of mazdutide on body weight, HbA1c, metabolic outcomes, and adverse events in adults with overweight\/obesity and\/or type 2 diabetes (T2D).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This systematic review and meta\u2010analysis included randomized controlled trials (RCTs) comparing mazdutide with placebo or active comparators in adults with overweight\/obesity and\/or T2D, identified through PubMed, Scopus, Web of Science, and\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      to 20 February 2026. Co\u2010primary outcomes were percent change in body weight and change in HbA1c. Secondary outcomes included other weight\u2010related and metabolic outcomes, as well as safety. Random\u2010effects models were used to generate pooled mean differences (MDs) or risk ratios with 95% confidence intervals, and the certainty of the evidence (COE) was assessed using GRADE.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Nine RCTs (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u20092292; most with low risk of bias) were included. In overweight\/obesity without diabetes, mazdutide 3, 4, and 6\u2009mg reduced body weight more than placebo (MDs \u22126.56%, \u22129.92%, and \u221211.1%, respectively; very low COE due to substantial heterogeneity and few trials). In T2D, mazdutide 4 and 6\u2009mg reduced body weight and HbA1c versus placebo (moderate COE) and also outperformed dulaglutide for both outcomes. Mazdutide also improved waist circumference, lipids, liver enzymes, and uric acid levels. Gastrointestinal adverse events were more frequent, but serious adverse events and treatment discontinuation rates were comparable with those of the comparators.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Mazdutide was associated with dose\u2010dependent reductions in body weight and HbA1c, with broader metabolic benefits in predominantly Chinese adults with obesity and\/or T2D. Longer\u2010term, multi\u2010ethnic studies are needed to confirm durability, generalizability, and cardiovascular safety.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.71058","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T03:32:04Z","timestamp":1783395124000},"page":"8777-8794","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy and Safety of the Dual Glucagon\u2010Like Peptide\u20101 and Glucagon Receptor Agonist Mazdutide in Predominantly Chinese Adults With Obesity and\/or Type 2 Diabetes: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5681-6522","authenticated-orcid":false,"given":"A. B. 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