{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T17:03:54Z","timestamp":1786122234593,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2120240615426"],"award-info":[{"award-number":["2120240615426"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003569","name":"Ministry of Food and Drug Safety","doi-asserted-by":"publisher","award":["RS\u20102026\u201025511535"],"award-info":[{"award-number":["RS\u20102026\u201025511535"]}],"id":[{"id":"10.13039\/501100003569","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Glucagon\u2010like peptide\u20101 receptor agonists (GLP\u20101 RAs) are increasingly prescribed for weight loss, yet their safety in clinical practice remains uncertain. We evaluated associations between weight\u2010management semaglutide or liraglutide initiation and safety outcomes in a multicentre cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>We used electronic health records from 13 South Korean hospitals (2018\u20132025) mapped to the OMOP Common Data Model. Adults initiating semaglutide or liraglutide were compared with propensity score\u2010matched non\u2010initiators in a new\u2010user design. Ten safety outcomes were assessed. Site\u2010specific hazard ratios were estimated using Cox proportional hazards models and combined via meta\u2010analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>After matching, 2357 semaglutide and 6953 liraglutide initiators were compared with 22\u2009602 and 68\u2009001 non\u2010initiators, respectively. Semaglutide was associated with increased risks of psychiatric disorders overall (hazard ratio 2.02, 95% confidence interval 1.30\u20133.14), anxiety disorder (2.39, 1.22\u20134.71), depressive disorder (3.42, 1.51\u20137.74), gastrointestinal dysmotility or obstruction (3.91, 1.42\u201310.82), and vision impairment (1.58, 1.04\u20132.41). Liraglutide was associated with increased risks of psychiatric disorders overall (1.66, 1.36\u20132.03), anxiety disorder (1.68, 1.45\u20131.96), depressive disorder (1.51, 1.14\u20132.00), hepatic impairment (1.46, 1.16\u20131.83), pancreatobiliary disorder (1.33, 1.09\u20131.63), pancreatitis\/cholangitis\/cholelithiasis (1.40, 1.18\u20131.68), and vision impairment (1.34, 1.16\u20131.55). Sensitivity analyses were consistent overall, although semaglutide\u2010associated vision impairment and liraglutide\u2010associated hepatic impairment were not significant in some analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>GLP\u20101 RA initiation for weight loss was associated with higher risks of selected psychiatric and gastrointestinal outcomes compared with non\u2010initiators, with heterogeneity across agents. These findings underscore the importance of careful patient selection and monitoring.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.71065","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T03:40:27Z","timestamp":1783395627000},"page":"8649-8659","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>GLP<\/scp>\n                    \u20101 Receptor Agonists for Weight Loss and Risk of Major Safety Outcomes: A Multicentre Cohort Study"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-2329-6279","authenticated-orcid":false,"given":"Jisu","family":"Park","sequence":"first","affiliation":[{"name":"School of Pharmacy Sungkyunkwan University  Suwon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7253-6515","authenticated-orcid":false,"given":"Ju Hwan","family":"Kim","sequence":"additional","affiliation":[{"name":"School of Pharmacy Sungkyunkwan University  Suwon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6363-1999","authenticated-orcid":false,"given":"Yoon Seob","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biomedical Informatics Ajou University School of Medicine  Suwon Republic of Korea"},{"name":"Center for Biomedical Informatics Research Ajou University Medical Center  Suwon Republic of Korea"},{"name":"Department of Medical Sciences Graduate School of Ajou University  Suwon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2821-9447","authenticated-orcid":false,"given":"Gyeongmin","family":"Lim","sequence":"additional","affiliation":[{"name":"School of Pharmacy Sungkyunkwan University  Suwon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3563-9504","authenticated-orcid":false,"given":"Hong Ji","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Family Medicine Hallym University Sacred Heart Hospital  Anyang Republic of Korea"},{"name":"Department of Data Science Hallym University  Chuncheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0119-5818","authenticated-orcid":false,"given":"Sang Youl","family":"Rhee","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Kyung Hee University College of Medicine  Seoul Republic of Korea"},{"name":"Center for Digital Health Kyung Hee University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7113-9527","authenticated-orcid":false,"given":"Seonghoon","family":"Hwang","sequence":"additional","affiliation":[{"name":"School of Pharmacy Sungkyunkwan University  Suwon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9294-7926","authenticated-orcid":false,"given":"Daeun","family":"Cho","sequence":"additional","affiliation":[{"name":"School of Pharmacy Sungkyunkwan University  Suwon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8966-0598","authenticated-orcid":false,"given":"Minyoung","family":"Kim","sequence":"additional","affiliation":[{"name":"HUBASE Co., Ltd.  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3658-2351","authenticated-orcid":false,"given":"Bo\u2010Yeon","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, Soonchunhyang University Bucheon Hospital Soonchunhyang University College of Medicine  Bucheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9305-4686","authenticated-orcid":false,"given":"Chang Won","family":"Jeong","sequence":"additional","affiliation":[{"name":"Medical AI Team Wonkwang University Hospital  Iksan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1715-2062","authenticated-orcid":false,"given":"Dae\u2010Yeon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Soonchunhyang University Cheonan Hospital  Cheonan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8714-0828","authenticated-orcid":false,"given":"Hang A","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Hallym University, Dongtan Sacred Heart Hospital  Hwaseong\u2010si Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4909-2308","authenticated-orcid":false,"given":"Min\u2010Ho","family":"Kim","sequence":"additional","affiliation":[{"name":"Informatization Department Ewha Womans University Seoul Hospital  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5471-5747","authenticated-orcid":false,"given":"Seong Hwan","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Chung\u2010Ang University Hospital  Seoul 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