{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T14:51:10Z","timestamp":1787669470387,"version":"build-2736575974"},"reference-count":46,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100013671","name":"Sun Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013671","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate and compare the efficacy, safety, and immunogenicity of a synthetic semaglutide injection (Test semaglutide) with Wegovy (Reference semaglutide) injection for weight management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      This randomized, Phase III, non\u2010inferiority study included adults with obesity or overweight with or without comorbidities from 21 centers in India. A total of 270 patients with body mass index \u2265\u200930\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      or \u2265\u200927\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      with the presence of at least one of the weight\u2010related comorbidities (hypertension, dyslipidemia or type 2 diabetes mellitus) were randomized (2:1) to receive either Test semaglutide (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u2009177) or Reference semaglutide injection (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200990) once weekly with dose escalation from 0.25 to 2.4\u2009mg. The primary endpoint was percentage change in bodyweight from baseline to Week 24.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Out of 267 randomized patients, 246 completed the study. At Week 24, mean percent weight change from baseline was \u221213.8%\u2009\u00b1\u20094.28% in Test and \u221214.1%\u2009\u00b1\u20094.11% in Reference groups with least\u2010squares mean difference of 0.26% (95% CI: \u22120.86% to 1.39%), meeting the criterion for non\u2010inferiority. The proportion of patients with \u2265\u20095% and \u2265\u200910% weight loss were 96.40% and 80.60% in Test, and 98.80% and 80.00% in Reference groups, respectively at Week 24. Improvements in body mass index, waist circumference, SF\u201036 total score, and glycemic parameters were comparable between groups. Treatment\u2010emergent adverse events were reported in 72.30% and 76.70% in the Test and Reference groups, respectively, with gastrointestinal events being the most common.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Test synthetic semaglutide was found to be non\u2010inferior to Reference semaglutide in weight management with or without comorbidities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      Prospectively registered on the Clinical Trials Registry\u2014India, CTRI\/2025\/04\/085487 [Registered on: 24\/04\/2025],\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/ctri.nic.in\/Clinicaltrials\/pmaindet2.php?EncHid=MTIwNjMx&amp;Enc=&amp;userName=\">https:\/\/ctri.nic.in\/Clinicaltrials\/pmaindet2.php?EncHid=MTIwNjMx&amp;Enc=&amp;userName=<\/jats:ext-link>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.71069","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T08:36:43Z","timestamp":1783327003000},"page":"8602-8612","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Semaglutide Injection Once\u2010Weekly for Weight Management in Adults: Results From A Randomized Phase\n                    <scp>III<\/scp>\n                    , Active\u2010Controlled Study"],"prefix":"10.1111","volume":"28","author":[{"given":"Unnikrishnan","family":"Ambika Gopalakrishnan","sequence":"first","affiliation":[{"name":"Chellaram Diabetes Institute  Pune Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ameya","family":"Joshi","sequence":"additional","affiliation":[{"name":"Bhaktivedanta Hospital and Research Institute  Thane Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harish","family":"Kumar","sequence":"additional","affiliation":[{"name":"Amrita Institute of Medical Sciences and Research Centre  Kochi Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richa","family":"Giri","sequence":"additional","affiliation":[{"name":"G.S.V.M Medical College  Kanpur Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjiv","family":"Maheshwari","sequence":"additional","affiliation":[{"name":"Jawahar Lal Nehru Medical College  Ajmer Rajasthan India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valluri Satya","family":"Prasad","sequence":"additional","affiliation":[{"name":"King George Hospital  Visakhapatnam Andhra Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jitendra","family":"Shukla","sequence":"additional","affiliation":[{"name":"Moti Lal Nehru Medical College  Prayagraj Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rekha","family":"M. 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