{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T04:39:00Z","timestamp":1792471140162,"version":"4.5.0"},"reference-count":33,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To characterise baseline clinical, anatomical, and genetic cardiovascular risk profiles in participants enrolled in the VOLTAIRE (Evaluation of Polygenic Scores and CT Imaging in Risk Factor Modification in Patients with Type 2 Diabetes) study and examine concordance across these domains.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This analysis included adults with T2D who completed baseline computed tomography coronary angiography (CTCA) and polygenic risk score (PRS) assessment prior to randomisation in the VOLTAIRE study. Coronary atherosclerosis was evaluated using coronary artery calcium (CAC) score and CTCA\u2010derived stenosis severity. Clinical risk was assessed using the New Zealand Society for the Study of Diabetes 5\u2010year cardiovascular risk calculator. Polygenic risk for coronary artery disease was assessed using a genome\u2010wide PRS and categorised into tertiles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 126 participants with T2D (mean age 57.5\u2009\u00b1\u20098.7\u2009years; 62.7% male), coronary atherosclerotic burden was highly heterogeneous: 34.9% had CAC\u2009=\u20090, whereas 19.8% had CAC \u2265\u2009400. Moderate\u2010to\u2010severe coronary stenosis (\u2265\u200950%) was present in 40.5% of participants overall, including 20.4% of those classified as low clinical risk. PRS distribution was variable (low 37.3%, intermediate 35.7%, high 27.0%). Overlap between anatomical, genetic, and clinical domains\u00a0was limited, with only 8.7% of participants classified as high risk across all three.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Substantial heterogeneity and limited overlap\u00a0exist between anatomical, genetic, and clinical cardiovascular risk measures in T2D. These findings support a multimodal approach to risk assessment integrating imaging and genetic profiling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n                      ; ID: NCT07091162\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.71072","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T03:25:50Z","timestamp":1783567550000},"page":"8861-8869","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Baseline Computed Tomography Coronary Angiography and Polygenic Risk Profiles in Adults With Type 2 Diabetes: A Cross\u2010Sectional Analysis From the\n                    <scp>VOLTAIRE<\/scp>\n                    Study"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1026-9922","authenticated-orcid":false,"given":"Ruofei (Trophy)","family":"Chen","sequence":"first","affiliation":[{"name":"Monash Victorian Heart Institute Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam J.","family":"Nelson","sequence":"additional","affiliation":[{"name":"Monash Victorian Heart Institute Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2672-0949","authenticated-orcid":false,"given":"Sophia","family":"Zoungas","sequence":"additional","affiliation":[{"name":"School of Public Health and Preventive Medicine Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robyn A.","family":"Clark","sequence":"additional","affiliation":[{"name":"Caring Future Institute, College of Nursing and Health Sciences Flinders University  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Tan","sequence":"additional","affiliation":[{"name":"Monash Victorian Heart Institute Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther F.","family":"Davis","sequence":"additional","affiliation":[{"name":"Monash Victorian Heart Institute Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa C.","family":"Southey","sequence":"additional","affiliation":[{"name":"Monash Victorian Heart Institute Monash University  Melbourne Victoria Australia"},{"name":"Department of Clinical Pathology The University of Melbourne  Melbourne Victoria Australia"},{"name":"Cancer Epidemiology Division Cancer 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Monash Health  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert L.","family":"O'Reilly","sequence":"additional","affiliation":[{"name":"Monash Victorian Heart Institute Monash University  Melbourne Victoria Australia"},{"name":"Precision Medicine, School of Clinical Sciences at Monash Health Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline S.","family":"Dron","sequence":"additional","affiliation":[{"name":"Centre for Genomic Medicine Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"Nicholls","sequence":"additional","affiliation":[{"name":"Monash Victorian Heart Institute Monash University  Melbourne Victoria 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