{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T04:38:57Z","timestamp":1792471137924,"version":"4.5.0"},"reference-count":25,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:00:00Z","timestamp":1783036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:00:00Z","timestamp":1783036800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Glucagon\u2010like peptide\u20101 receptor agonists (GLP\u20101RAs) have transformed the pharmacological management of obesity, producing substantial and sustained weight loss during active treatment. However, discontinuation of therapy is frequently followed by significant weight regain, raising important questions regarding the durability of treatment effects and optimal strategies for treatment withdrawal. Recent systematic reviews and meta\u2010analyses consistently demonstrate that weight regain after GLP\u20101RA discontinuation is substantial and follows a characteristic trajectory, with a large proportion occurring during the early post\u2010cessation period. This front\u2010loaded pattern suggests that the initial months after treatment cessation represent a critical window influencing long\u2010term outcomes. Mechanistically, post\u2010cessation weight regain appears to reflect the interaction of multiple processes. These include restoration of appetite following withdrawal of pharmacological GLP\u20101 signalling, compensatory increases in orexigenic hormones such as ghrelin, alterations in incretin balance including glucose\u2010dependent insulinotropic polypeptide (GIP) and potential adaptive changes in GLP\u20101 receptor signalling pathways during prolonged pharmacological exposure, although evidence for a direct role in post\u2010cessation weight regain remains limited. These converging mechanisms have important clinical implications, as abrupt discontinuation may result in a transient mismatch between increased biological drive for weight regain and the sudden loss of pharmacological appetite suppression. In this context, strategies aimed at mitigating early weight regain are of increasing interest. Recent randomised evidence suggests that reduced\u2010intensity pharmacological maintenance may attenuate weight regain compared with abrupt discontinuation. However, whether structured tapering strategies can successfully facilitate treatment discontinuation remains unknown and requires prospective evaluation.<\/jats:p>","DOI":"10.1111\/dom.71075","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T09:48:15Z","timestamp":1783072095000},"page":"8769-8776","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Early Weight Regain After\n                    <scp>GLP<\/scp>\n                    \u20101 Receptor Agonist Discontinuation: Mechanisms and Implications for Treatment De\u2010Escalation Strategies"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1163-8937","authenticated-orcid":false,"given":"M. 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