{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T04:39:02Z","timestamp":1792471142743,"version":"4.5.0"},"reference-count":44,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"publisher","award":["2024ZD0523300"],"award-info":[{"award-number":["2024ZD0523300"]}],"id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Middle\u2010aged and older adults with overweight or obesity are at increased risk of cardiometabolic multimorbidity (CMM), yet validated prediction tools tailored to this population remain limited. This study aimed to develop and validate a multidimensional nomogram integrating metabolic, functional and psychological predictors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      Using the China Health and Retirement Longitudinal Study (CHARLS) data (2011 and 2015), 3965 overweight\/obese adults with a body mass index (BMI)\u2009\u2265\u200924.0\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      were randomly split into development (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20092775) and validation (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091190) sets. Candidate predictors spanned socio\u2010demographic, lifestyle, functional, psychological and biochemical factors. External validation included 8180 overweight\/obese participants from the US Health and Retirement Study (HRS). Least absolute shrinkage and selection operator and multivariable logistic regression were applied to build a nomogram. Performance was assessed by area under the curve (AUC), calibration and decision curve analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>CMM prevalence was 3.91%. Eight variables were retained: residence, Activities of daily living (ADL) score, the Center for Epidemiologic Studies Depression Scale (CESD\u201010) score, haemoglobin A1c (HbA1c), hypertension, arthritis, dyslipidaemia and memory disorder. AUCs were 0.871 (95% CI: 0.838\u20130.905) (development), 0.817 (95% CI: 0.768\u20130.867) (validation) and 0.733 (95% CI: 0.714\u20130.751) in HRS external validation, with acceptable calibration in CHARLS and evidence of underestimation in HRS that improved after intercept recalibration, and clear net benefit. Positive predictive values were additionally reported to support clinical interpretation under the low CMM prevalence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This nomogram integrating metabolic, functional and psychological predictors demonstrated strong discrimination in the CHARLS cohort and maintained adequate discriminative performance in a cross\u2010national external validation using the US HRS cohort despite differences in population characteristics and measurement instruments, supporting its potential utility for early CMM risk stratification in overweight\/obese older adults. The external HRS validation showed fair discrimination, suggesting that model recalibration may be necessary before broad cross\u2010national implementation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.71077","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T03:26:34Z","timestamp":1783394794000},"page":"8825-8835","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Cross\u2010Nationally Validated Nomogram for Cardiometabolic Multimorbidity in Overweight\/Obese Older Adults:\n                    <scp>CHARLS<\/scp>\n                    and\n                    <scp>HRS<\/scp>\n                    Cohorts"],"prefix":"10.1111","volume":"28","author":[{"given":"Yanhan","family":"Wei","sequence":"first","affiliation":[{"name":"Institute of Health Informatics, University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyi","family":"He","sequence":"additional","affiliation":[{"name":"School of Life Course and Population Sciences, King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5524-616X","authenticated-orcid":false,"given":"Huizhen","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Life Course and Population Sciences, King's College London  London UK"},{"name":"Chengdu University of Traditional Chinese Medicine, Clinical Medical School  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanzhong","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Life Course and Population Sciences, King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,6]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.11.010"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2021.109119"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.22208"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.025250"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanwpc.2022.100550"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102018\u2010021768"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.922824"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213\u20108587(15)00086\u20108"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741\u20107015\u201011\u201087"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21950"},{"issue":"1","key":"e_1_2_13_12_1","first-page":"83","article-title":"Predictive Values of Body Mass Index and Waist Circumference for Risk Factors of Certain Related Diseases in Chinese Adults: Study on Optimal Cut\u2010Off Points of Body Mass Index and Waist Circumference in Chinese Adults","volume":"15","author":"Zhou B. F.","year":"2002","journal-title":"Biomedical and Environmental Sciences"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(03)15268\u20103"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.7008"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916\u2010021\u201002126\u2010x"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.38361"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40520\u2010024\u201002732\u20108"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2023.104959"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201087444\u2010z"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjgh\u20102020\u2010004042"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.1052547"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dys203"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu16142277"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyu067"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-3797(18)30622-6"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/JGP.0b013e3181dba6d2"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.7326\/M14\u20100697"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2023.107792"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2024.1389635"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002571"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468\u20102667(17)30074\u20109"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11883\u2010023\u201001132\u2010z"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.306301"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.25.2.155"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1003094"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2025.1642243"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13670\u2010018\u20100254\u20100"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2017.06.009"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1037\/hea0000737"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.653651"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2015.3"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102020\u2010038404"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2021.707062"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2024.1421328"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/stats8020045"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dom-pubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dom.71077","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/dom.71077","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dom-pubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dom.71077","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T03:52:29Z","timestamp":1792468349000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.onlinelibrary.wiley.com\/doi\/10.1111\/dom.71077"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,6]]},"references-count":44,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1111\/dom.71077"],"URL":"https:\/\/doi.org\/10.1111\/dom.71077","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/DOM.71077\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71077\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71077\/v1\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71077\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71077\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71077\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.71077\/v1\/review1","asserted-by":"object"}]},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"value":"1462-8902","type":"print"},{"value":"1463-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,6]]},"assertion":[{"value":"2026-05-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}