{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T04:38:47Z","timestamp":1792471127980,"version":"4.5.0"},"reference-count":23,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>In December 2022, semaglutide injections for weight management were marketed in Denmark. Pre\u2010marketing trials documented high efficacy when adherence to the treatment and the recommended dose titration schedule was followed. This study aimed to describe real\u2010world use of semaglutide, including dose titration, discontinuation patterns and effectiveness on body weight in adults with overweight or obesity treated in primary care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>This retrospective, observational study included adults prescribed semaglutide for weight management between December 2022 and May 2024 in one general practise in Denmark. The primary outcome was the relative mean change in body weight from baseline to 12\u2010months follow\u2010up in individuals who had not discontinued treatment and who had a baseline and a follow\u2010up weight.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 206 individuals were included (76% women; mean age 48\u2009years, standard deviation (SD) 13). Mean baseline body weight was 105\u2009kg (SD 23.8). Twelve months after treatment initiation, 38% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200978) had permanently discontinued semaglutide, whilst 15% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200930) had temporarily discontinued (paused) semaglutide. Approximately 48% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200998) remained on treatment. Amongst these, 40% were treated with \u2264\u20091.0\u2009mg\/week, 30% with 1.7\u2009mg\/week and 30% with 2.4\u2009mg\/week. Relative mean body weight change after 12\u2009months was \u221213.6 (95% CI \u221215.0 to \u221212.2)%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Based on the experience from utilisation in a single general practise, semaglutide for weight management is frequently discontinued and titrated slower and to lower maintenance doses in real\u2010world clinical practise than in the approved labelling. Despite this, the observed mean weight loss for individuals who had not discontinued treatment was substantial.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.71092","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T03:39:48Z","timestamp":1783568388000},"page":"8905-8912","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Real\u2010World Use of Semaglutide for Weight Management: Dose Titration, Discontinuation Patterns and Weight Changes"],"prefix":"10.1111","volume":"28","author":[{"given":"Mie Dyberg","family":"Skandov","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacology Copenhagen University Hospital\u2014Bispebjerg  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrine McLain","family":"Christensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Copenhagen University Hospital\u2014Bispebjerg  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dagmar Abelone","family":"Dalin","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Copenhagen University Hospital\u2014Bispebjerg  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janne","family":"Unkerskov","sequence":"additional","affiliation":[{"name":"L\u00e6gerne Kanaltorvet  Albertslund Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1262-3769","authenticated-orcid":false,"given":"Andreas","family":"Br\u00f8nden","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Copenhagen University Hospital\u2014Bispebjerg  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Lund","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Copenhagen University Hospital\u2014Bispebjerg  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikkel Bring","family":"Christensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Copenhagen University Hospital\u2014Bispebjerg  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6596-4199","authenticated-orcid":false,"given":"Kristian","family":"Karstoft","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Copenhagen University Hospital\u2014Bispebjerg  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2032183"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.31982"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/00325481.2025.2482274"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.24315"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc24\u20101082"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.16364"},{"key":"e_1_2_8_8_1","unstructured":"A.Mailhac L.Pedersen I.Petersen A.Pottegaard H.S\u00f8rensen andR.Thomsen \u201cDiscontinuation of Semaglutide Therapy for Weight Loss: Population\u2010Based Study of the First 77 310 Users in Denmark \u201din European Association for the Study of Diabetes (EASD) Annual Meeting. Vienna Austria 2025."},{"issue":"5","key":"e_1_2_8_9_1","article-title":"The Use of Shared Medication Record as Part of Medication Reconciliation at Hospital Admission Is Feasible","volume":"61","author":"Munck L. 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