{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T04:41:16Z","timestamp":1792384876724,"version":"4.4.0"},"reference-count":58,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["8240153568"],"award-info":[{"award-number":["8240153568"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The effects of individual sodium\u2010glucose cotransporter\u20102 inhibitors (SGLT2 inhibitors) and glucagon\u2010like peptide\u20101 receptor agonists (GLP\u20101 receptor agonists) on ventricular arrhythmias (VAs) remain uncertain. This study aimed to comprehensively compare their effects on VAs and cardiovascular outcomes in patients with type 2 diabetes mellitus (T2DM) and\/or heart failure (HF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Four databases were systematically searched from inception through May 16, 2026, to identify randomised controlled trials. Nine outcomes were evaluated, including VAs, cardiovascular mortality, all\u2010cause mortality and hospitalization for heart failure (HHF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirty\u2010seven publications, corresponding to 32 independent RCTs and 140\u2009156 participants, were included. Most SGLT2 inhibitors and GLP\u20101 receptor agonists did not significantly increase VA risk; empagliflozin showed a statistically significant but exploratory signal for lower VA risk in the T2DM network (OR 0.31, 95% CI 0.11\u20130.86). Dapagliflozin in the HF network and empagliflozin and liraglutide in the T2DM network, were associated with lower cardiovascular and all\u2010cause mortality. SGLT2 inhibitors consistently reduced HHF across both networks. Dapagliflozin was associated with lower AKI risk, while albiglutide and liraglutide were associated with lower hypoglycemia risk; however, these safety findings should be interpreted cautiously because adverse\u2010event reporting was not uniform across trials. Several safety outcomes were based on sparse events and non\u2010uniform adverse\u2010event reporting; no statistically significant increase in diabetic ketoacidosis risk was detected for empagliflozin and the semaglutide fracture signal should be interpreted cautiously. Because the evidence networks were largely placebo\u2010centered and lacked closed loops, treatment rankings and between\u2010drug comparisons depend heavily on the transitivity assumption. These rankings, including\n                      <jats:italic>P<\/jats:italic>\n                      \u2010score rankings, should be regarded as exploratory and should not be interpreted as head\u2010to\u2010head comparative evidence.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>SGLT2 inhibitors consistently reduced HHF risk across the HF and T2DM networks and selected agents showed mortality benefits in clinically relevant populations. Empagliflozin showed an exploratory signal for lower VA risk in the T2DM network; however, this finding requires confirmation in trials with prespecified and adjudicated arrhythmia endpoints. Safety signals, including DKA and fracture, should be interpreted cautiously because adverse\u2010event ascertainment was not uniform across trials.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.71094","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T03:11:30Z","timestamp":1783653090000},"page":"9753-9766","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and Safety of\n                    <scp>SGLT2<\/scp>\n                    Inhibitors and\n                    <scp>GLP<\/scp>\n                    \u20101 Receptor Agonists on Ventricular Arrhythmias and Cardiovascular Events: A Disease\u2010Stratified Network Meta\u2010Analysis"],"prefix":"10.1111","volume":"28","author":[{"given":"Wen\u2010Ting","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine Dongzhimen Hospital  Beijing China"},{"name":"Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui\u2010Xing","family":"Liu","sequence":"additional","affiliation":[{"name":"Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao\u2010Hao","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Dongzhimen Hospital  Beijing China"},{"name":"Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying\u2010Kun","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Dongzhimen Hospital  Beijing China"},{"name":"Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Yi\u2010Cai","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Dongzhimen Hospital  Beijing 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